Computer simulation of cardiac arrhythmias and of defibrillating electric shocks. Effects of antiarrhythmic drugs
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Our computer simulations allow us to study several mechanisms inducing self-sustained conduction troubles leading to an uncoordinated contraction of cardiac fibres related to ventricular tachycardia and fibrillation. These simulations show that an important parameter is the wave length which is defined by the product of the conduction velocity by the refractory period duration. Grossly, any process which makes increase this wave lenght has an antiarrhythmic effect. On the contrary, any process which makes decrease the wave lenght is going to favor reentries and arrhythmias.
KeywordsConduction Velocity Electric Shock Refractory Period Cardiac Cell Electrical Mapping
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