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The Roles of Chromatin Remodelling Factors in Replication

  • Ana Neves-Costa
  • Patrick Varga-WeiszEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 41)

Abstract

Dynamic changes of chromatin structure control DNA-dependent events, including DNA replication. Along with DNA, chromatin organization must be replicated to maintain genetic and epigenetic information through cell generations. Chromatin remodelling is important for several steps in replication: determination and activation of origins of replication, replication machinery progression, chromatin assembly and DNA repair. Histone chaperones such as the FACT complex assist DNA replication within chromatin, probably by facilitating both nucleosome disassembly and reassembly. ATP-dependent nucleosome remodelling enzymes of the SWI/SNF family, in particular imitation switch (ISWI)-containing complexes, have been linked to DNA and chromatin replication. They are targeted to replication sites to facilitate DNA replication and subsequent chromatin assembly.

Keywords

Proliferate Cell Nuclear Antigen Sister Chromatid Cohesion Origin Recognition Complex Chromatin Assembly Histone Chaperone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

Acknowledgments

We thank Tom Sexton for constructive criticism of this manuscript. ANC is funded by Fundação para a Ciência e Tecnologia. Work in the Varga-Weisz laboratory is funded by the Biotechnology and Biosciences Research Council, the Association for International Cancer Research, St. Andrews (AICR) and the European Network of Excellence (NoE).

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Authors and Affiliations

  1. 1.Babraham InstituteCambridgeUK

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