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Chromatin Modifications in DNA Repair

  • Ashby J. Morrison
  • Xuetong ShenEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 41)

Abstract

A requirement of nuclear processes that use DNA as a substrate is the manipulation of chromatin in which the DNA is packaged. Chromatin modifications cause alterations of histones and DNA, and result in a permissive chromatin environment for these nuclear processes. Recent advances in the fields of DNA repair and chromatin reveal that both histone modifications and chromatin-remodeling complexes are essential for the repair of DNA lesions, such as DNA double strand breaks (DSBs). In particular, chromatin-modifying complexes, such as the INO80, SWR1, RSC, and SWI/SNF ATP-dependent chromatin-remodeling complexes and the NuA4 and Tip60 histone acetyltransferase complexes are implicated in DNA repair. The activity of these chromatin-modifying complexes influences the efficiency of the DNA repair process, which ultimately affects genome integrity and carcinogenesis. Thus, the process of DNA repair requires the cooperative activities of evolutionarily conserved chromatin-modifying complexes that facilitate the dynamic chromatin alterations needed during repair of DNA damage.

Keywords

Nijmegen Breakage Syndrome Histone H2AX H2AX Phosphorylation Histone Acetyltransferase Complex INO80 Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. 1.University of Texas, M.D. Anderson Cancer CenterDepartment of Carcinogenesis, Science Park Research DivisionSmithvilleUSA

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