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Structure and Function of Protein Modules in Chromatin Biology

  • Kyoko L. Yap
  • Ming-Ming ZhouEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 41)

Abstract

Chromatin-mediated gene transcription or silencing is a dynamic process in which binding of various proteins or protein complexes can displace nucleosomal histones from DNA to relieve repression or drive the gene into a highly repressed, silent state. Covalent modifications to DNA and histones associated with chromatin structural change play a crucial role in transcriptional regulation, with particular modifications on certain residues associated with a specific transcriptional outcome. In recent years a number of structural domains have been identified within chromatin-associated proteins, including DNA or RNA binding domains, protein-protein interaction domains and domains that recognize specific covalent modifications to histone tails. In this review we discuss the structural features of these protein modules and the functional roles they play in chromatin biology.

Keywords

Spinal Muscular Atrophy Protein Module Origin Recognition Complex Protein Interaction Domain PWWP Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

Acknowledgments

This work was supported by a fellowship from the Terry Fox Foundation/National Cancer Institute of Canada (to K.L.Y.) and by grants from the National Institutes of Health (to M.-M.Z.).

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Authors and Affiliations

  1. 1.Structural Biology Program, Department of Physiology and BiophysicsMount Sinai School of Medicine, New York UniversityNew YorkUSA

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