Clinical PET pp 210-227 | Cite as

Infectious and Inflammatory Diseases

  • Kyung-Han Lee
  • June-Key Chung


Positron emission tomography (PET) with fluorine-18-fluoro-2-deoxyD-glucose (FDG) is a powerful tool to diagnose, stage, and monitor cancer patients. While this technique exploits the fact that enhanced glucose utilization leading to high FDG uptake is characteristic for a variety of cancers, FDG is not a tumor-specific agent. Infectious or inflammatory lesions with high concentrations of activated leukocytes and/or macrophages also show significantly elevated levels of FDG accumulation. Such lesions can be mistaken for malignancy in patients undergoing PET studies for cancer evaluation, which may lead to false-positive interpretation. However, in patients with known or suspected infectious or inflammatory lesions, FDG-PET can be used to quantify the pathologic increase in glucose metabolism of inflammatory processes and may be a powerful clinical tool for the diagnosis of monitoring inflammatory activity. FDG-PET thus may be useful for evaluating such diseases caused by infections from a variety of bacteria, mycobacteria, virus, and fungi, and also infectious or inflammatory processes.


Positron Emission Tomography Single Photon Emission Compute Tomography Positron Emission Tomography Imaging Giant Cell Arteritis Chronic Granulomatous Disease 
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© Springer Science+Business Media New York 2004

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  • Kyung-Han Lee
  • June-Key Chung

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