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Fc Receptor Phagocytosis

  • Randall G. Worth
  • Alan D. Schreiber
Chapter
  • 780 Downloads
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Antigen recognition by cells of the immune system occurs via many mechanisms. One important family of receptors involved in the recognition of immunoglobulin (Ig) coated particles and complexes are Fc receptors. Fc receptors recognize the Fc portion of Ig and are accordingly grouped into subfamilies. They are named depending upon which class of Ig they bind. The major Fc receptors are Fcã receptors which bind IgG, FcáR that bind IgA and FcåR bind IgE.1, 2, 3, 4 Fc receptors are responsible for such functions as endocytosis,5, 6, 7, 8 phago-cytosis,9, 10, 11, 12 granule release,13, 14, 15, 16, 17 reactive mediator release and cell activation/cytotoxicity.18, 19, 20, 21, 22, 23Fc receptors are found on specific cell types corresponding to their ability to recognize Ig. For example, Fcγ receptors are found primarily on eosinophils, basophils and mast cells where they trigger histamine release from intracellular granules whereas Fcã receptors are found primarily on neutrophils, macrophages and monocytes where they can detect and phagocytose IgG coated pathogens.14,15

Keywords

Lipid Raft Leukoc Biol Immunoreceptor Tyrosine Base Activation Motif Complement Receptor Type Leukocyte Adhesion Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Eurekah.com and Springer Science+Business Media 2005

Authors and Affiliations

  • Randall G. Worth
    • 1
  • Alan D. Schreiber
    • 1
  1. 1.Division of Hematology and Oncology, Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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