Small GTP Binding Proteins and the Control of Phagocytic Uptake

  • Agnès Wiedemann
  • Jenson Lim
  • Emmanuelle Caron
Part of the Medical Intelligence Unit book series (MIUN)


Phagocytosis is a conserved cellular process in Eukaryotes. A multi-step process, it involves the recognition of paniculate material, e.g., microbes and apoptotic cells, their F-actin-driven engulfment and the subsequent destruction of the phagocytized material in phagolysosomes. Distinct sets of small GTP-binding proteins (Rap1, Arf6, Rho and Rab proteins) control and coordinate the successive steps of the phagocytic process. Moreover, these proteins are often targeted by microbial virulence factors. This review summarizes and discusses the evidence implicating Ras, Rho, Arf and Rab-family GTPases in the signalling pathways driving particle recognition and uptake.


Yersinia Enterocolitica Phagocytic Uptake Particle Binding Membrane Delivery Phagocytic Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© and Springer Science+Business Media 2005

Authors and Affiliations

  • Agnès Wiedemann
    • 1
  • Jenson Lim
    • 1
  • Emmanuelle Caron
    • 1
  1. 1.Department of Biological Sciences, Centre for Molecular Microbiology and InfectionImperial College LondonLondonUK

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