Regulation of Phagocytosis by FcγRIIb and Phosphatases

  • Susheela Tridandapani
  • Clark L. Anderson
Part of the Medical Intelligence Unit book series (MIUN)


Phagocytosis of immune-complexes is a dynamic process that is accompanied by the generation of inflammatory/tissue damaging products. Recent advances in the field indicate that this process is subject to regulation by inhibitory Fcγ receptors and intracellular phosphatases, including the inositol phosphatases SHIP-1, SHIP-2 and PTEN, and the protein tyrosine phosphatase SHP-1. This chapter will describe the role of the inhibitory Fc receptor, FcγRIIb, and the phosphatases in modulating the signaling events leading to phagocytosis and the accompanying inflammation.


Focal Adhesion Kinase Protein Tyrosine Phosphatase Phosphatase Domain Inositol Polyphosphate Inositol Phosphatase 
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Copyright information

© and Springer Science+Business Media 2005

Authors and Affiliations

  • Susheela Tridandapani
    • 1
  • Clark L. Anderson
    • 1
  1. 1.Department of Internal Medicine and the Dorothy M. Davis Heart and Lung Research InstituteThe Ohio State UniversityColumbusUSA

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