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Calcium Signaling during Phagocytosis

  • Alirio J. Melendez
Chapter
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Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Phagocytosis is important for a wide diversity of organisms. From simple unicellular organisms that use phagocytosis to eat, to complex metazoans in which phagocytic cells represent an essential branch of the immune system. Evolution has armed cells with a fantastic repertoire of molecules that serve to bring about this complex event regardless of the organism or specific molecules concerned. However, all phagocytic processes are driven by a finely controlled rearrangement of the actin cytoskeleton where calcium (Ca2+) signals play important roles. Ca2+ plays many roles in cytoskeletal changes by affecting the actions of a number of contractile proteins, as well as being a cofactor for the activation of a number of intracellular signaling proteins, known to play important roles during phagocytosis. In the mammalian immune system, the requirement of Ca2+ for the initial steps in phagocytosis, and the subsequent phagosome maturation, can be quite different depending on the type of cell and on the type of receptor that is driving phagocytosis.

Keywords

Human Neutrophil Complement Receptor Internal Store Sphingosine Kinase Intracellular Free Calcium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  • Alirio J. Melendez
    • 1
  1. 1.Department of Physiology Faculty of MedicineNational University of SingaporeSingapore

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