Application of CNGM to Learning and Memory
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Before we introduce a tentative CNGM of learning and memory at a cellular level, we need to consider the relevant rules of synaptic plasticity, which represent knowledge about the basic mechanisms of cellular and molecular memory storage. Then we need to enhance these rules with connections to gene/protein regulatory network (GPRN) of genes and proteins that are relevant to learning and memory. Finally, a provisional CNGM of learning and memory will be constructed. In what follows, we will discuss only the activity-dependent plasticity of excitatory synaptic connections of the brain, because they are thought to mediate the information storage within biological neural networks (Kandel et al. 2000).
KeywordsSynaptic Plasticity Modification Threshold Postsynaptic Membrane High Frequency Stimulation CREB Phosphorylation
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