Simplified Action Potential Models
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The basic motivations for simplifying the AP mathematical models are: To make computer simulation of excitation wave propagation in 3D-tissue model with complex configuration feasible. To find a qualitative relationship between normal AP generation and propagation.
There are at least three known approaches used to simplify AP mathematical models: Based on singular perturbation theory Based on clamp-experiment data Based on the Van der Pole relaxation generator
In some cases, the sensitivity analysis  allows the introduction of some simplifications to modern sophisticated mathematical models.
KeywordsAction Potential Duration Outward Current Singular Perturbation Theory Repolarization Phase Versus Rest
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