Pathophysiology of Contractile Dysfunction in Heart Failure

  • Naranjan S. Dhalla
  • Jingwei Wang
  • Xiaobing Guo
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 225)


Heart failure is a clinical syndrome in which the cardiac output is inadequate to meet the metabolic needs of the body.1 Essentially, it is a pathological state in which impaired cardiac pump activity decreases ejection of the blood and impedes venous return. The pathologic stimuli for the occurrence of heart failure can be categorized as follows: (a) conditions which lead to the development of pressure or volume overload (b) conditions which produce abnormal cardiac muscle contraction and relaxation and (c) conditions which limit ventricular filling.2 A wide variety of diseases (Table I) including valvular heart disease, ischemic heart disease, cardiomyopathy, septal defects, hypertension and pericardial disease can result in heart failure. 3-6


Heart Failure Congestive Heart Failure Sarcoplasmic Reticulum Dilate Cardiomyopathy Human Heart 
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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Naranjan S. Dhalla
  • Jingwei Wang
  • Xiaobing Guo

There are no affiliations available

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