Excitatory Amino Acid Receptors and Phosphoinositide Breakdown: Facts and Perspectives

  • Max Récasens
  • Ebrahim Mayat
  • Janique Guiramand


Although phosphoinositides were isolated from brain membranes by Folch in 1949, stimulated phosphoinositide metabolism by neuroactive substances was discovered in 1953 by Hokin and Hokin, who showed that the incorporation of 32P into phospholipids of the pancreas was augmented by acetylcholine. In 1961, Dittmer and Dawson (Dawson and Dittmer, 1961; Dittmer and Dawson, 1961) identified these polyphosphoinositides as phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). However, the notion that phosphoinositide metabolism is associated with receptor function was only proposed in 1969 by Durell and co-workers, while a few years later (1975) Michell assumed a close relation between phosphoinositide metabolism and intracellular calcium. Finally, the missing link (inositol trisphosphate) between membrane receptor-coupled phosphoinositide metabolism and the changes in intracellular calcium originating from internal stores was discovered by Berridge and Irvine in 1984.


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Copyright information

© Macmillan Publishers Limited 1991

Authors and Affiliations

  • Max Récasens
    • 1
  • Ebrahim Mayat
    • 1
  • Janique Guiramand
    • 1
  1. 1.Laboratoire de Neurobiologie de l’Audition (Université Montpellier II)MontpellierFrance

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