Calcium Ions and Ventricular Arrhythmias
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Considerable experimental evidence suggests that calcium antagonist agents can have antiarrhythmic effects on both ischaemic and reperfusion arrhythmias. Furthermore, adequate electrophysiological mechanisms have been described whereby an increased cytosolic calcium could promote ischaemic or reperfusion arrhythmias, acting by somewhat different mechanisms. None the less, calcium antagonists are not recognized as ventricular antiarrhythmic agents and this paradox will briefly be analysed in this chapter after a review of the basic experimental evidence.
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