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Tissues Specific Action of Thyroid Hormones: Insights from Knock out Animal Models

  • Michelina Plateroti
  • Cristina Angelin-Duclos
  • Frederic Flamant
  • Jacques Samarut
Chapter
Part of the Endocrine Updates book series (ENDO, volume 22)

Abstract

Thyroid hormones, T3 and T4, are known to control the development and the function of many tissues in vertebrates. The paradigm of these effects is metamorphosis in amphibians. The ability to create targeted mutations in specific genes in the mouse has allowed to generate relevant mouse models in which either the production of thyroid hormone or the function of thyroid hormone receptors (TRs) and related products is defective. These models begin to provide helpful information to understand the molecular basis of thyroid hormones action in vivo.

Keywords

Thyroid Hormone Congenital Hypothyroidism Thyroid Hormone Receptor Oligodendrocyte Precursor Cell External Granular Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Michelina Plateroti
    • 1
  • Cristina Angelin-Duclos
    • 1
  • Frederic Flamant
    • 1
  • Jacques Samarut
    • 1
  1. 1.UMR 5665 CNRS-ENS INRA LA913Laboratoire de Biologie Moléculaire et Cellulaire de l’Ecole Normale Supérieure de LyonLyon cedex 07France

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