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Learning from Nature’s Experiments on the Thyroid Hormone Receptor; X-Ray Structures of RTH Mutant Ligand-Binding Domains

  • Ben H. Sandler
  • John D. Baxter
  • Robert J. Fletterick
Chapter
  • 134 Downloads
Part of the Endocrine Updates book series (ENDO, volume 22)

Abstract

The syndrome of resistance to thyroid hormone (RTH) is characterized by unresponsiveness to thyroid hormone by the product(s) of one of the human thyroid hormone receptor-β (hTR β) genes. It is an uncommon disorder, but thyroid hormone receptor-β (hTR β) genes. It is an uncommon disorder, but nonetheless one that requires diagnosis by the physician to avoid mismanagement of the patient. Study of the syndrome has resulted in substantial insights into the mechanisms for thyroid action. Most cases are due to mutations in the hTR β ligand-binding domain (LBD). Studies of X-ray crystal structures of this domain have provided additional insights into how these mutations affect receptor function, that in turn reveal more information about mechanisms of TR function in general. In this review, we discuss what has been learned from studies using X-ray crystallography of receptors containing mutations found in RTH.

Keywords

Thyroid Hormone Nuclear Receptor Hinge Region Thyroid Hormone Receptor Dimerization Interface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Ben H. Sandler
    • 1
  • John D. Baxter
    • 2
  • Robert J. Fletterick
    • 1
  1. 1.Molecular Structures GroupUniversity of California San FranciscoUSA
  2. 2.Metabolic Research UnitUniversity of California San FranciscoUSA

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