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Lessons Learned from TR-β Mutant Mice

  • Fredric E. Wondisford
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Part of the Endocrine Updates book series (ENDO, volume 22)

Abstract

Thyroid hormone receptors (TR) are cellular homologues of the viral erythroblastic leukemia oncogene (v-erbA). TRs (c-erbA isoforms) are derived from two separate gene loci in mammals: α and β1. The α locus in humans is located on chromosome 17 (17q11.2) and the β locus is on chromosome 3 (3p24.3). The TR-α gene undergoes alternative splicing generating two c-erbA isoforms: TR-αl and α2. TR-α1 is a bona fide thyroid hormone receptor, whereas alternative splicing of the C-terminus of α2 generates a non-T3 binding isoform. The TR-β gene generates two major isoforms due to alternative promoter utilization: TR-β1 and TR-β2. This results in two beta thyroid hormone receptors with different amino termini (Figure 1).

Keywords

Thyroid Hormone Outer Hair Cell Congenital Hypothyroidism Thyroid Hormone Receptor External Granular Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Fredric E. Wondisford
    • 1
  1. 1.Section of Endocrinology, Department of MedicineUniversity of ChicagoUSA

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