Neurotrophic Support of Midbrain Dopaminergic Neurons

  • Oliver von BohlenEmail author
  • Klaus Unsicker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 651)


In this chapter we review work on neurotrophic factors for midbrain dopaminergic neurons mainly from the past decade, with a focus on neurotrophins and fibroblast growth factors. We summarize data obtained from animal models of Parkinson’s disease, review analyses of neurotrophin, neurotrophin receptor and FGF-2 knockout mice and put these into context with data obtained from patients with Parkinson’s disease and from postmortem studies. We provide a brief overview on several other factors (EGF, TGF-α, IGF, CNTF, PDGF, interleukins) and their capacity to promote survival and protect lesioned DAergic neurons. TGF-βs are reviewed in a separate chapter (Roussa et al, this volume).


Substantia Nigra Dopaminergic Neuron Basic Fibroblast Growth Factor Neurotrophin Receptor BDNF mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Interdisciplinary Center for Neurosciences, NeuroanatomyUniversity of HeidelbergHeidelbergGermany

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