Clinical Applications of Ischemic Preconditioning

  • Yochai Birnbaum
  • Robert A. Kloner
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 194)


The term “Ischemic preconditioning” is used to describe the phenomenon of protection of the myocardium from ischemic-reperfusion injury by preceding short sublethal ischemic episodes. Ischemic preconditioning is one of the most powerful means known to protect the myocardium during subsequent ischemic-reperfusion insult. However, its mechanisms are still unknown. Understanding its mechanisms and development of “preconditioning-mimetic ”drugs may allow myocardial protection in various clinical situations in which the heart is exposed to ischemia. In the following chapter we shall discuss human myocardial preconditioning by brief ischemic episodes in four major clinical situations:
  1. 1.

    Cardiopulmonary bypass: ischemic preconditioning as an alternative method to cardioplegia for the preservation of the myocardium.

  2. 2.

    Percutaneous transluminal coronary angioplasty: changes in severity of pain and electrocardiographic manifestations of ischemia during repeated balloon occlusion.

  3. 3.

    Acute myocardial infarction: the effects of previousanginaon infarct size, left ventricular function, ventricular arrhythmias, and prognosis.

  4. 4.

    Adaptation to angina: augmentation of maximal effort during repeated exertion.



Acute Myocardial Infarction Thrombolytic Therapy Ischemic Precondition Ischemic Episode Silent Ischemia 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Yochai Birnbaum
  • Robert A. Kloner

There are no affiliations available

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