Anti-ischemic Effects of the ATP-sensitive Potassium Channel Opener During Coronary Angioplasty
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Since Gross and co-workers1 found that glibenclamide completely blocked the infarct size-reducing effect afforded by ischemic preconditioning in canine hearts, it has been widely known that the ATP-sensitive potassium (KATP) channel activation plays an important role in myocardial protection against ischemia-reperfusion injury in several species, and a number of laboratories have demonstrated that KATP channel openers such as nicorandil,2 bimakalim,3 and aprikalim1 mimic the cardioprotective effect of ischemic preconditioning.
KeywordsCoronary Angioplasty Ischemic Precondition Cardioprotective Effect Balloon Inflation Canine Heart
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- 8.Mizumura T, Nithipatikom K, Gross GJ. Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs. Cardiovasc Res. In pressGoogle Scholar