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Adenosine Cardioprotection and Potential Mechanisms

  • Robert D. Lasley
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Part of the Developments in Cardiovascular Medicine book series (DICM, volume 194)

Abstract

The purine nucleoside adenosine exerts numerous physiological effects in normal mammalian myocardium, including modulation of coronary blood flow and negative chronotropic, dromotropic, and anti-adrenergic properties. The cellular mechanisms of these effects have, for the most part, been well delineated.1 In the last several years it has been established that adenosine also exerts effects in ischemic and reperfused myocardium. Infusion of adenosine prior to ischemia enhances postischemic ventricular function and reduces infarct size. Endogenous adenosine also appears to modulate myocardial ischemic and reperfusion injury. This review will summarize the beneficial effects of adenosine in reversibly and irreversibly injured myocardium and address potential mechanisms of action.

Keywords

Infarct Size Ischemic Precondition Cardioprotective Effect Myocardial Stunning Endogenous Adenosine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1997

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  • Robert D. Lasley

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