A Gene Complex Controlling Segmentation in Drosophila

  • E. B. Lewis


The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repressor of the complex. The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene’s cis-regulatory element.


Cuticular Pattern Arate Section Double Mutant Combination Rearran Gements Bithorax Gene Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Lewis E. B. Cold Spring Harb. Symp. quant. Biol 16, 159–174 (1951).Google Scholar
  2. 2.
    Lewis E. B. Caryologia Suppl 6, 100–105 (1954).Google Scholar
  3. 3.
    Lewis E. B. Am. Nat. 89, 73–89 (1955).Google Scholar
  4. 4.
    Lewis E. B. Am. Zoologist 3, 33–56 (1963).Google Scholar
  5. 5.
    Lewis E. B. in Role of Chromosomes in Development (ed. Locke M.) 231–252 (Academic New York, 1964).Google Scholar
  6. 6.
    Lewis E. B. in Heritage from Mendel (ed. Brink R. A.) 17–47 (University of Wisconsin Press Madison, 196Google Scholar
  7. 7.
    Lewis E. B. Proc. 12th int. Congr. Genet. 2, 96–97 (1968).Google Scholar
  8. 8.
    Morata G. & Garcia-Bellido A. Wilhelm Roux’ Archiv. 179, 125–143 (1976).Google Scholar
  9. 9.
    Morata G. J. Embryol. exp. Morph. 34, 19–31 (1975).Google Scholar
  10. 10.
    Wheeler M. R. Ann. ent. Soc. Am. 53, 133–137 (1960).Google Scholar
  11. 11.
    Lawrence P. A., Green S. M. & Johnston P., J. Embryol. exp. Morph. 43, 233–245 (1978).Google Scholar
  12. 12.
    Tazima Y. The Genetics of the Silkworm (Logos London, (1964).Google Scholar
  13. 13.
    Auerbach C. Trans. R. Soc. Edinb. 58, 787–815 (1936).Google Scholar
  14. 14.
    Bodenstein D. in Biology of Drosophila (ed. Demerec, M.) 275–367 (Wiley New York, (1950).Google Scholar
  15. 15.
    Lindsley O. L. & Grell E. H. Carnegie Inst. of Wash. Publ. No. 627 (1968).Google Scholar
  16. 16.
    Puro J. & Nygren T. Hereditas 81, 237–248 (1975).Google Scholar
  17. 17.
    Garcia-Bellido A. Am. Zoologist 17, 613–629 (1977).Google Scholar
  18. 18.
    Garcia-Bellido A., Ripoll P., and Morata G. Nature new Biol. 245, pp251–253 (1973).Google Scholar
  19. 19.
    Morata G. & Lawrence P. A. Nature 265, 211–216 (1977).Google Scholar
  20. 20.
    Kiger J. A.,Jr Devl. Biol. 50, 187–200 (1976).Google Scholar
  21. 21.
    Davis R. L. & Kiger J. A., Jr Devl. Biol. 58, 114–123 (1977).Google Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • E. B. Lewis
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

Personalised recommendations