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Ionizing Radiation and Tumor Production

  • E. B. Lewis
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Abstract

Ionizing radiation has long been a promising agent for studying the mechanism of cancer induction. The dose of radiation delivered to a given tissue can usually be determined with much greater precision than can the dose of a chemical agent. By varying the radiation dose, or dose rate, while holding other factors constant, and then measuring the yield of malignant conditions, the investigator can hope to quantitate the kinetics of the cancer induction process. To be sure, there are many obstacles. For example, to assay for malignancy after exposure of somatic cells to radiation is much more difficult than to assay for chromosomal or gene damage after exposure of germ cells to radiation. Doses as low as several hundred rads, when delivered to the organism acutely, may not only kill large numbers of somatic cells but may disrupt the immunological and hormonal systems in such a way as to modify the yield of malignancies in a complex manner.

Keywords

Lymp Hosarcoma Tumor Production Leukemia Death American Radiolo Gist Code Rubric 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson R. E., and K. Ishida. 1964. Malignant Lymphoma in Survivors of the Atomic Bomb in Hiroshima. Annals of Internal Medicine, 61:853–862.PubMedGoogle Scholar
  2. Beach S. A., and G. W. Dolphin. 1962. A Study of the Relationship Between X-Ray Dose Delivered to the Thyroids of Children and the Subsequent Development of Malignant Tumors. Physics in Medicine and Biology, 6: 583–598.CrossRefGoogle Scholar
  3. Bizzozero O. J., Jr., K. G. Johnson, and A. Ciocco, with the collaboration of T. Hoshino, T. Itoga, S. Toyoda, and S. Kawasaki. 1966. Radiation-Related Leukemia in Hiroshima and Nagasaki 1946–1964. I. Distribution, Incidence and Appearance Time. New England Journal of Medicine, 274: 1095–1101.PubMedCrossRefGoogle Scholar
  4. Carter C. O., K. A. Evans, and A. M. Stewart. 1961. Maternal Radiation and Down’s Syndrome (Mongolism). Lancet, 2:1042.CrossRefGoogle Scholar
  5. Court Brown W. M., K. E. Buckton, and A. S. McLean. 1965. Quantitative Studies of Chromosome Aberrations in Man Following Acute and Chronic Exposure to X-Rays and Gamma Rays. Lancet, 1:1239–1241.CrossRefGoogle Scholar
  6. Court-Brown (sic), W. M., and R Doll. 1957. Leukaemia and Aplastic Anaemia in Patients Irradiated for Ankylosing Spondylitis (Medical Research Council, Special Report Series No. 295). Her Majesty’s Stationery Office London, England 135 pp.Google Scholar
  7. Court-Brown (sic), W. M.. 1965. Mortality from Cancer and Other Causes After Radiotherapy for Ankylosing Spondylitis. British Medical Journal, 2: 1327–1332.CrossRefGoogle Scholar
  8. Directory of Medical Specialists. 1951. Chicago, Illinois: A. N. Marquis Co. Vol. 5, 1694 pp.Google Scholar
  9. Doll R. 1962. II. Age Differences in Susceptibility to Carcinogenesis in Man. British Journal of Radiology, 35: 31–36.PubMedCrossRefGoogle Scholar
  10. Dublin L. I., and M. Spiegelman. 1948. Mortality of Medical Specialists, 1938–1942. Journal of the American Medical Association, 137:1519–1524.PubMedCrossRefGoogle Scholar
  11. Faber M. 1957. “Radiation-Induced Leukaemia in Denmark,” Advances in Radiobiology (Proceedings of the Fifth International Conference on Radiobiology held in Stockholm on 15th–19th August, 1956), G. C. de Hevesy, A. G. Forssberg, and J. D. Abbatt, Eds. Springfield, Illinois: Charles C Thomas. Pp. 397–404.Google Scholar
  12. Faber M., E. Andreasen, and H. Uhrbrand. 1958. Further Studies on Irradiation-Induced Leukaemia in Denmark, Transactions of the Sixth Congress of the European Society of Haematology, A. Videbaek, Ed. Basel, S. Karger Switzerland, and New York, New York. Part 2. Pp. S211–S213.Google Scholar
  13. Fraumeni J. F., Jr., and R. W. Miller. 1967. Epidemiology of Human Leukemia: Recent Observations. Journal of the National Cancer Institute, 38:593–605.PubMedGoogle Scholar
  14. Graham S., M. L. Levin, A. M. Lilienfeld, L. M. Schuman, R. Gibson, J. E. Dowd, and L. Hempelmann. 1966. Preconception, Intrauterine, and Postnatal Irradiation as Related to Leukemia, Epidemiological Approaches to the Study of Cancer and Other Chronic Diseases (National Cancer Institute Monograph 19), W. Haenszel, Ed. U.S. Department of Health, Education and Welfare, Public Health Service, National Cancer Institute Bethesda, Maryland. Pp. 347–371.Google Scholar
  15. Gunz F. W., and H. R. Atkinson. 1964. Medical Radiations and Leukemia: Retrospective Survey. British Medical Journal, 1:389–393.PubMedCrossRefGoogle Scholar
  16. Hempelmann L. H. 1968. Risk of Thyroid Neoplasms after Irradiation in Childhood. Science, 160:159–163.PubMedCrossRefGoogle Scholar
  17. Hempelmann L. H., J. W. Piper, G. J. Burke, R. Terry, and W. R. Ames. 1967. Neoplasms in Persons Treated with X-Rays in Infancy for Thymic Enlargement. A Report of the Third Follow-up Survey. Journal of the National Cancer Institute, 38:317–341.PubMedGoogle Scholar
  18. Hutchison G. 1968. Leukemia in Patients with Cancer of the Cervix Uteri Treated with Radiation. A Report Covering the First Five Years of an International Study. Journal of the National Cancer Institute, 40:951–982.PubMedGoogle Scholar
  19. Lewis E. B. 1957. Leukemia and Ionizing Radiation. Science, 125:965–972.PubMedCrossRefGoogle Scholar
  20. Lewis E. B. 1963. Leukemia, Multiple Myeloma and Aplastic Anemia in American Radiologists. Science, 142:1492–1494.PubMedCrossRefGoogle Scholar
  21. MacMahon B. 1962. Prenatal X-Ray Exposure and Childhood Cancer. Journal of the National Cancer Institute, 28:1173–1191.PubMedGoogle Scholar
  22. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death (International Committee for the Preparation of the Decennial Revision of International Lists of Diseases and Causes of Death, 6th Revision). 1948. Geneva. Switzerland: World Health Organization. Vol. 1, 376 pp., Vol. 2 (Alphabetical Index), 524 pp.Google Scholar
  23. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death (Based on the Recommendations of the Seventh Revision Conference, 1955, and Adopted by the Ninth World Health Assembly under the WHO Nomenclature Regulations). 1957. Geneva, Switzerland: World Health Organization. Vol. 1, 393 pp.; Vol. 2 (Alphabetical Index), 540 pp.Google Scholar
  24. March H. C. 1944. Leukemia in Radiologists. Radiology, 43:275–278.Google Scholar
  25. Pifer J. W., E. T. Toyocka, R. W. Murray, W. R. Ames, and L. H. Hempelmann. 1963. Neoplasms in Children Treated with X-Rays for Thymic Enlargement. I. Neoplasms and Mortality. Journal of the National Cancer Institute, 31:1333–1356.PubMedGoogle Scholar
  26. Pochin E. E. 1960. Leukemia Following Radioiodine Treatment of Thyrotoxicosis. British Medical Journal, 2:1545–1550.PubMedCrossRefGoogle Scholar
  27. Pohl W. 1960. Plasmocytoma due to Roentgen Injury. Medizinische Klinik, 55:1839–1842.PubMedGoogle Scholar
  28. Saenger E. L., G. E. Thoma, and E. A. Tompkins. 1968. Incidence of Leukemia Following Treatment of Hyperthyroidism. Journal of the American Medical Association, 205:855–862.PubMedCrossRefGoogle Scholar
  29. Schull W. J., and J. V. Neel. 1962. Maternal Radiation and Mongolism. Lancet, 1:537–538.CrossRefGoogle Scholar
  30. Seltser R., and P. E. Sartwell. 1965. The Influence of Occupational Exposure to Radiation on the Mortality of American Radiologists and Other Medical Specialists. American Journal of Epidemiology, 81:2–22.PubMedGoogle Scholar
  31. Sigler A. T., A. M. Lilienfeld, B. H. Cohen, and J. E. Westlake. 1965. Radiation Exposure in Parents of Children with Mongolism (Down’s syndrome). Bulletin of the Johns Hopkins Hospital, 117:374–399.Google Scholar
  32. Simpson C. L., L. H. Hempelmann, and L. M. Fuller. 1966. Neoplasia in Children Treated with X-Rays in Infancy for Thymic Enlargement Radiology, 64:840–845.Google Scholar
  33. Stewart A. 1961. Aetiology of Childhood Malignancies. British Medical Journal, 1:452–460.PubMedCrossRefGoogle Scholar
  34. Stewart A., W. Pennybacker, and R. Barber. 1962. Adult Leukaemias and Diagnostic X-Rays. BritishMedical Journal, 2:882–890.Google Scholar
  35. Stewart A., J. Webb, and D. Hewitt. 1958. A Survey of Childhood Malignancies. British Medical Journal, 1:1495–1508.PubMedCrossRefGoogle Scholar
  36. Uchida I. A., R. Holunga, and C. Lawler. 1968. Maternal Radiation and Chromosomal Aberrations. Lancet, 9:1045–1049.CrossRefGoogle Scholar
  37. Wald N., G. E. Thoma, Jr., and G. Broun, Jr. 1962. Hematologic Manifestations of Radiation Exposure in Man, Progress in Hematology, L. M. Tocantins, Ed. Grune & Stratton New York, New York, and London, England. Vol. III. Pp. 1–52.Google Scholar
  38. Wanebo C. K., K. G. Johnson, K. Sato, and T. W. Thorslund. 1968a. Breast Cancer After Exposure to the Atomic Bombings of Hiroshima and Nagasaki. New England Journal of Medicine, 279:667–671.CrossRefGoogle Scholar
  39. Wanebo C. K. 1968b. Lung Cancer Following Atomic Radiation. American Review of Respiratory Diseases, 98:778–787.Google Scholar
  40. Werner S. C., A. M. Gittelsohn, and A. B. Brill. 1961. Leukemia Following Radioiodine Therapy of Hyperthyroidism. Journal of the American Medical Association, 177:646–648.PubMedCrossRefGoogle Scholar
  41. Wood J. W., H. Tamagaki, S. Neriishi, T. Sato, W. F. Sheldon. P. G. Archer, H. B. Hamilton, and K. G. Johnson. 1969. Thyroid Carcinoma in Atomic Bomb Survivors Hiroshima and Nagasaki. American Journal of Epidemiology, 89:4–14.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • E. B. Lewis
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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