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Analysis of Lung Tumor Mortality in the Battelle Beagle Lifespan Experiment

  • E. B. Lewis
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Abstract

Forty beagles in the Battelle group between 12 and 43 months of age (mean age = 562 days) were given “single, 10–30 minute inhalation exposures to 239PuO2 aerosols via a mask’ [52]. Eighteen of the original 40 dogs died with lung tumors as the primary cause of death. Seventeen died of other causes, primarily pulmonary fibrosis, and in nine of these lung tumors were in evidence even though they had not developed to the point of causing death. Finally, five dogs were sacrificed for analysis of tissue distribution of plutonium. Sacrificed animals were asymptomatic for lung tumors and none had lung tumors at autopsy. Details of the experimental procedures and results are given by Park et al. [52].

Keywords

Carcino Genesis Minute Inhalation 
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References

  1. 52.
    J. F. Park, W. J. Blair and R. H. Busch. Progress in Beagle Dog Studies with Transuranium Elements at Batelle-Northwest. Health Physics 28: 803–810, 1972.CrossRefGoogle Scholar
  2. 68.
    Report of the Advisory Committee on the Biological Effects of Ionizing Radiations (BEIR). The Effects on Populations of Exposure to Low Levels of Ionizing Radiations. NAS/NRC, 1972.Google Scholar
  3. 69.
    M. C. Pike. A Method of Analysis of a Certain Class of Experiments in Carcinogenesis. Biometrics 22:142–161, 1966.PubMedCrossRefGoogle Scholar
  4. 70.
    P. J. Cook, R. Doll and S. A. Fellingham. A Mathematical Model for the Age Distribution of Cancer in Man. International Journal of Cancer 4:93–112, 1969.CrossRefGoogle Scholar
  5. 71.
    R. Doll. The Age Distribution of Cancer: Implications for Models of Carcinogenesis (with Discussion). J. Roy. Stat. Soc. Series A, 134: 133–166, 1971.CrossRefGoogle Scholar
  6. 72.
    R. Doll. II. Age Differences in Susceptibility to Carcinogenesis in Man. British Journal of Radiology 35:31–36, 1962.Google Scholar
  7. 73.
    L. Marinelli. Estimates of the Radiation Induced Leukemic Risk in Man, ANL Report 7760, Part II, Argonne National Laboratory, National Technical Information Service Springfield, VA, 1970.Google Scholar
  8. 74.
    F. Burbank. Patterns in Cancer Mortality in the United States: 1950–1967. National Cancer Institute Monograph 33, 594 pp., 1971.Google Scholar

Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • E. B. Lewis
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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