Molecular Regulation of Osteoblast Differentiation

  • Prasanna Bukka
  • Marc D. McKee
  • Andrew C. Karaplis
Part of the Topics in Bone Biology book series (TBB, volume 1)


Bone, the major component of the skeleton, is formed by two distinct ossification processes, intramembranous and endochondral. Intramembranous bone arises directly from mesenchymal cells condensing at ossification centers and transforming directly into osteoblasts. This form of ossification gives rise to the flat bones of the skull, parts of the clavicle, and the periosteal surface of long bones. Endochondral ossification differs from the intramembranous component in that it is formed in the presence of a cartilaginous blastema. It is a complex, multistep process requiring the sequential formation and degradation of cartilaginous structures that serve as templates for the developing axial and appendicular bones. This formation of calcified bone on a cartilage scaffold occurs not only during skeletogenesis but is an integral part of postnatal growth and fracture repair (Figure 1.1).


Bone Formation Osteoblast Differentiation High Bone Mass Mesenchymal Condensation Runt Domain 
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© Springer-Verlag London 2004

Authors and Affiliations

  • Prasanna Bukka
  • Marc D. McKee
  • Andrew C. Karaplis

There are no affiliations available

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