Anticoagulation in Pregnancy

  • Vera Regitz-ZagrosekEmail author
  • Christa Gohlke-Baerwolf
  • Bernard Iung
  • Petronella G. Pieper
Part of the Current Cardiovascular Therapy book series (CCT)


In pregnant women, anticoagulation is needed for women with mechanical valves, for women who are at increased risk of venous thrombembolism, those who have cardiomyopathies and severely impaired ejection fraction (EF), for high-risk patients with atrial fibrillation, those who have acute coronary syndromes and for some patients with congenital heart disease. The most frequently used drugs are Vitamin K antagonists, heparins, clopidogrel, and acetyl salicylic acid. They differ in the level of protection and risk they bear for the mother and her fetus and their precise use varies according to the specific indication. Both the indications and drugs have been discussed in the guidelines of the European Society of Cardiology on the management of cardiovascular diseases in pregnancy and were recently reviewed in European Heart Journal ((Regitz-Zagrosek et al. 2011) and Current Problems in Cardiology, in press). The present chapter is based on these publications.


Atrial Fibrillation Pulmonary Embolism International Normalize Ratio Venous Thromboembolism Oral Anticoagulant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Ejection fraction


International normalized ratio


Low molecular weight heparin


Unfractioned heparin


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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Vera Regitz-Zagrosek
    • 1
    • 2
    Email author
  • Christa Gohlke-Baerwolf
    • 3
  • Bernard Iung
    • 4
    • 5
  • Petronella G. Pieper
    • 6
  1. 1.Charité, University Medicine Berlin, Institute of Gender in Medicine (GiM)BerlinGermany
  2. 2.University Medicine Berlin, Center for Cardiovascular Research (CCR)BerlinGermany
  3. 3.Department of CardiologyHeart Center Bad KrozingenBad KrozingenGermany
  4. 4.Cardiology DepartmentAP-HP, Bichat HospitalParisFrance
  5. 5.University Paris Diderot, Sorbonne Paris CitéParisFrance
  6. 6.Department of CardiologyUniversity Medical Center Groningen, University of GroningenGroningenThe Netherlands

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