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Central Nervous System Tumor Markers

  • Trevor R. Jones
  • Darell D. Bigner
Chapter
Part of the Contemporary Biomedicine book series (CB, volume 2)

Abstract

Tumors of the human central nervous system (CNS) can be divided into two large groups: primary and metastatic. Although primary CNS tumors are less common than metastatic tumors, primary tumors are seen at a rate of about 10,000–15,000 per year or 0.5–2/100,000 population. This is a higher incidence than is seen in Hodgkin’s disease. Primary CNS tumors are also the most common solid tumors of childhood (Jellinger, 1978; Posner et al., 1979). Although a large number of systems for the classification of primary CNS neoplasia has been generated during the last century, primary intracranial tumors are now categorized using one of a small number of systems. The most common primary CNS tumors of adults are of glial origin, including astrocytomas, glioblastomas, oligodendrogliomas, and ependymomas. Other tumors are of questioned origin. Included here are medulloblastoma, a tumor of childhood, and hemangioblastoma, a tumor classically described as being of blood vessel origin; that concept is, however, now under scrutiny. Several types of meningiomas develop from the tissues covering the brain, the leptomeninges. The adenohypophysis is the source of four types of pituitary adenomas; some of these benign tumors secrete pituitary hormones. A discussion of CNS tumor morphology and classification is outside the limits of this review and if the reader wishes a comprehensive treatment if this subject, he is referred to Burger and Vogel (1976) and Russell and Rubinstein (1977).

Keywords

Glial Fibrillary Acidic Protein Pituitary Adenoma Glutamine Synthetase Myelin Basic Protein Central Nervous System Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

References

  1. Allen, J. C., J. Nisselbaum, F. Epstein, G. Rosen, and M. K. Schwartz (1979), J. Neurosurg. 51, 368.PubMedGoogle Scholar
  2. Allen, J. P., J. W. Kendall, R. McGilvra, T. L. Lamorena, and A. Castro (1974a), Arch. Neurol. 31, 325.PubMedGoogle Scholar
  3. Allen, J. P., J. W. Kendall, R. McGilvra, and C. Vancura (1974b), J. Clin. Endo. Metab. 31, 586.Google Scholar
  4. Allen, N. (1961), Neurol. 11, 578.Google Scholar
  5. Allen, N. (1972), Prog. Exptl. Tumor Res. 17, 291.Google Scholar
  6. Allen, N., and E. Reagan (1964), Arch. Neurol. 11, 144.PubMedGoogle Scholar
  7. Anlyan, A. J., and A. Starr (1952), Cancer 5, 578.PubMedGoogle Scholar
  8. Antanitus, D. S., B. H. Choi, and L. W. Lapham (1975), Brain Res. 89, 363.PubMedGoogle Scholar
  9. Aronson, S. M., J. H. Garcia, and B. E. Aronson (1964), Cancer 17, 558.PubMedGoogle Scholar
  10. Assies, J., A. P. M. Schellekins, and J. L. Touber (1978), J. Clin. Endo. Metab. 46, 576.Google Scholar
  11. Augusti-Tocco, G., L. Casola, and A. Grasso (1973), Cell Dijf. 2, 157.Google Scholar
  12. Bagshawe, K. D. (1977), in Tumor Markers (K. Griffiths, A. M. Neville, and C. G. Pierrepont, eds.), University Park Press, Baltimore, pp. 90–100.Google Scholar
  13. Bagshawe, K. D., and S. Harland (1976), Cancer 38, 112.PubMedGoogle Scholar
  14. Bagshawe, K. D., A. H. Orr, and A. G. J. Rushworth (1968), Nature 217, 950.PubMedGoogle Scholar
  15. Balagura, S., A. G. Frantz, E. M. Housepian, and P. W. Carmel (1979), J. Neurosurg. 51, 42.PubMedGoogle Scholar
  16. Ballou, B., G. Levine, T. R. Hakala, and D. Solter (1979), Science 206, 844.PubMedGoogle Scholar
  17. Bignami, A., and D. Dahl (1977), J. Histochem. Cytochem. 25, 466.PubMedGoogle Scholar
  18. Bignami, A., L. F. Eng, D. Dahl, and C. T. Uyeda (1972), Brain Res. 43, 429.PubMedGoogle Scholar
  19. Bignami, A., D. Dahl, and D. C. Rueger (1977), in Mechanisms, Regulation and Special Functions of Protein Synthesis in the Brain (S. Roberts, A. Lajtha, and W. H. Gispen, eds.), Elsevier/North Holland, Amsterdam, pp. 153–160.Google Scholar
  20. Bigner, D. D., S. H. Bigner, J. Pontén, B. Westermark, E. Ruoslahti, H. Herschman, and C. J. Wikstrand (1981), J. Neuropath. Exptl. Neurol., 40, 201.Google Scholar
  21. Bigner, S. H., T. R. Jones, R. D. Serano, H. R. Hershman, and D. D. Bigner (1980), J. Neuropath. Exptl. Neurol. 39, 341.Google Scholar
  22. Bock, E. (1978), J. Neurochem. 30, 7.PubMedGoogle Scholar
  23. Bock, E., and J. Dissing (1975), Scand. J. Immunol. Suppl. 2, 31.Google Scholar
  24. Bodansky, O. (1975), Biochemistry of Human Cancer Academic Press, New York, p. 657.Google Scholar
  25. Braun, P. E., and S. W. Brostoff (1977), in Myelin (P. Morrell, ed.), Plenum, New York, pp. 201–232.Google Scholar
  26. Braunstein, G. D., J. L. Vaitukaitis, P. P. Carbone, and G. T. Ross (1973), Ann. Int. Med. 78, 39.PubMedGoogle Scholar
  27. Breen, G. A. M., and J. de Vellis (1975), Exptl. Cell Res. 91, 159.PubMedGoogle Scholar
  28. Brightman, M. W. (1968), Prog. Brain Res. 29, 19.PubMedGoogle Scholar
  29. Brightman, M. W., and T. S. Reese (1969), J. Cell Biol. 40, 648.PubMedGoogle Scholar
  30. Buckell, M., and M. C. Robertson (1965), Brit. J. Cancer 19, 83.PubMedGoogle Scholar
  31. Burger, P. C., and F. S. Vogel (1976), Surgical Pathology of the Nervous System and its Coverings, Wiley, New York, pp. 623.Google Scholar
  32. Cicero, T. J., W. M. Cowan, B. W. Moore, and V. Suntzelf (1970), Brain Res. 18, 25.PubMedGoogle Scholar
  33. Constantopoulos, A., K. Antonakakis, N. Matsaniotis, and Z. Kapsalakis (1976), Neurochir. 19, 169.Google Scholar
  34. Cuello, A. C., G. Galfre, and C. Milstein (1979), Proc. Natl. Acad. Sci. USA 76, 3532.PubMedGoogle Scholar
  35. Dahl, D. (1976), Biochim. Biophy. Acta 420, 142.Google Scholar
  36. Dahl, D., and A. Bignami (1976), Brain Res. 116, 150.PubMedGoogle Scholar
  37. Deck, J. H. N., L. F. Eng. J. Bigbee, and S. M. Woodcock (1978), Acta Neuropath. 42, 183.PubMedGoogle Scholar
  38. Delaunoy, J.-P., G. Roussel, and P. Mandel (1977), CR Acad. Sci. Paris 285, 801.Google Scholar
  39. Delpech, B., A. Delpech, M. N. Vidard, N. Girard, J. Tayot, J. C. Clement, and P. Creissard (1978), Brit. J. Cancer 37, 33.PubMedGoogle Scholar
  40. de Vellis, J., and G. Brooker (1973), in Tissue Culture of the Nervous System (G. Sato, ed.), Plenum, New York, pp. 231–245.Google Scholar
  41. de Vellis, J., and D. Inglish (1968), J. Neurochem. 15, 1061.PubMedGoogle Scholar
  42. de Vellis, J., J. F. McGinnis, G. A. M. Breen, P. LeVeille, K. Bennett, and K. McCarthy (1977), in Cell, Tissue and Organ Cultures in Neurobiology (S. Federoff and L. Hertz, eds.), Academic Press, New York, pp. 485–511.Google Scholar
  43. Dharker, S. R., R. S. Dharker, and B. D. Chaurasia (1976), J. Neurol. Neurosurg. Psych. 39, 1081.Google Scholar
  44. DiLorenzo, N., and L. Palma (1976), Lancet 1, 1077.Google Scholar
  45. DiLorenzo, N., L. Palma, and L. Ferrante (1977), Neurochir. 20, 19.Google Scholar
  46. Dittman, L., N. H. Axelsen, B. Norgaard-Pedersen, and E. Bock (1977), Brit. J. Cancer 35, 135.Google Scholar
  47. Dohan, F. C., P. L. Kornblith, G. R. Wellum, S. E. Pfeiffer, and L. Levine (1977), Acta Neuropath. 40, 123.PubMedGoogle Scholar
  48. Drummond, G. I., N. T. Iyer, and J. Keith (1962), J. Biol. Chem. 237, 3535.Google Scholar
  49. Duffy, P. E., L. Graff, and M. M. Rapport (1977), J. Neuropath. Exptl. Neurol. 36, 645.Google Scholar
  50. Eisenbarth, G. S., F. S. Walsh, and M. Nirenberg (1979), Proc. Natl. Acad. Sci. USA 76, 4913.PubMedGoogle Scholar
  51. Eng, L. F., and J. W. Bigbee (1978), Adv. Neurochem. 3, 43.Google Scholar
  52. Eng. L. F., and L. J. Rubinstein (1978), J. Histochem. Cytochem. 26, 513.Google Scholar
  53. Eng. L. F., J. J. Vand erhaeghen, A. Bignami, and B. Gerstl (1971), Brain Res. 28, 351.Google Scholar
  54. Fishman, J. S., and M. Hayashi (1962), J. Histochem. Cytochem. 10, 515.Google Scholar
  55. Fleisher, G. A., K. G. Wakim, and N. P. Goldstein (1957), Proc. Staff Meetings Mayo Clinic 32, 188.Google Scholar
  56. Fumagalli, R., and P. Paoletti (1971), Neurol. 11, 1149.Google Scholar
  57. Fumagalli, R., E. Grossi, P. Paoletti, and R. Paoletti (1964), J. Neurochem. 11, 561.PubMedGoogle Scholar
  58. Fumagalli, R., E. Grossi-Paoletti, P. Paoletti, and R. Paoletti (1966), J. Neurochem. 13, 1005.PubMedGoogle Scholar
  59. Fumagalli, R., S. Pezzotta, A. R. Racca, and P. Paoletti (1976), Pharm. Res. Comm. 8, 127.Google Scholar
  60. Gerhardt, W., J. Clausen, E. Christensen, and J. Rüsheda (1963), Acta Neurol. Scand. 39, 85.PubMedGoogle Scholar
  61. Giacobini, E. (1961), Science 134, 1524.PubMedGoogle Scholar
  62. Giacobini, E. (1962), J. Neurochem. 9, 169.PubMedGoogle Scholar
  63. Gold, P., and S. O. Freedman (1965a), J. Exptl. Med. 121, 439.Google Scholar
  64. Gold, P., and S. O. Freedman (1965b), J. Exptl. Med. 122, 467.Google Scholar
  65. Gomez, C. M., D. P. Richman, P. W. Berman, S. A. Burres, B. G. W. Arnason, and F. W. Fitch (1979), Biochem. Biophys. Res. Comm. 88, 575.PubMedGoogle Scholar
  66. Goridis, C., and M. Schachner (1978), in Biology of Brain Tumors (O.D. Laerum, D. D. Bigner, and M. F. Rajewsky, eds.), International Union Against Cancer, Geneva, pp. 158–171.Google Scholar
  67. Grasso, A., K. G. Haglid, H.-A. Hansson, L. Persson, and L. Ronnback (1977), Brain Res. 122, 582.PubMedGoogle Scholar
  68. Green, J. B., H. A. Oldewurtel, D. S. O’Doherty, F. M. Forster, and L. P. Sanchez-Longo (1957), Neurol. 7, 313.Google Scholar
  69. Green, J. B., H. A. Oldewurtel, D. S. O’Doherty, and F. M. Forster (1958), Arch. Neurol. Psych. 80, 148.Google Scholar
  70. Green, J. B., H. A. Oldewurtel, and F. M. Forster (1959), Neurol. 9, 540.Google Scholar
  71. Haglid, K., C.-A. Carlsson, and C.-A. Thulin (1970), Neurochir. 13, 19.Google Scholar
  72. Haglid, K., C.-A. Carlsson, and D. Stavrou (1973a), Acta Neuropath. 24, 187.PubMedGoogle Scholar
  73. Haglid, K. G., D. Stavrou, L. Ronnback, C.-A. Carlsson, and W. Weidenbach (1973b), J. Neurol. Sci. 20, 103.PubMedGoogle Scholar
  74. Hamberger, A., C. W. Cotman, A. Sellstrom, and C. T. Weiler (1977), in Dynamic Properties ofGlia Cells (E. Schoffeniels, G. Franck, L. Hertz, and D. B. Tower, eds.), Pergamon, Oxford, pp. 163–172.Google Scholar
  75. Hamprecht, B. (1978), in Biology of Brain Tumors (O. D. Laerum, D. D. Bigner, and M. F. Rajewsky, eds.), International Union Against Cancer, Geneva, pp. 143–157.Google Scholar
  76. Hansen, N. E., H. Karle, A. Jensen, and E. Bock (1977), Acta Neurol. Scand. 55, 418.PubMedGoogle Scholar
  77. Harik, S. I., and C. H. Sutton (1979), Cancer Res. 39, 5010.PubMedGoogle Scholar
  78. Hayakawa, T., Y. Ushio, T. Mori, N. Arita, T. Yoshimine, Y. Maeda, K. Shimizu, and A. Myoga (1979), Stroke 10, 685.PubMedGoogle Scholar
  79. Hayakawa, T., K. Morimoto, Y. Ushio, T. Mori, T. Yoshimine, A. Myoga, and H. Mogami (1980), J. Neurosurg. 52, 229.PubMedGoogle Scholar
  80. Henn, F. A., D. J. Anderson, and D. G. Rustand (1976), Brain Res. 101, 341.PubMedGoogle Scholar
  81. Herschman, H. R. (1978), in Biology of Brain Tumors (O. D. Laerum, D. D. Bigner, and M. F. Rajewsky, eds.), International Union Against Cancer, Geneva pp. 172–183.Google Scholar
  82. Herschman, H. R., and M. P. Lerner (1973), Nature New Biol. 241, 242.PubMedGoogle Scholar
  83. Hertz, L. (1977), in Cell, Tissue and Organ Cultures in Neurobiology (S. Fedoroff and L. Hertz, eds.), Academic Press, New York, pp. 39–71.Google Scholar
  84. Hildebrand, J. (1973), Eur. J. Cancer 9, 621.PubMedGoogle Scholar
  85. Hill, S. A., E. C. Ellison, and E. W. Martin (1979), in Immunodiagnosis of Human Cancer (R. B. Herberman, ed.), Elsevier/North Holland, New York, p. 33.Google Scholar
  86. Holmes, R. S. (1977), Eur. J. Biochem. 78, 511.PubMedGoogle Scholar
  87. Hydén, H., and B. McElven (1966), Proc. Natl. Acad. Sci. USA 55, 354.PubMedGoogle Scholar
  88. Isobe, T., and T. Okuyama (1978), Eur. J. Biochem. 89, 379.PubMedGoogle Scholar
  89. Isobe, T., T. Nakajima, and T. Okuyama (1977), Biochim. Biophys. Acta 494, 222.PubMedGoogle Scholar
  90. Isobe, T., A. Tsugita, and T. Okuyama (1978), J. Neurochem. 30, 921.PubMedGoogle Scholar
  91. Jacque, C. M., C. Vinner, M. Kujas, M. Raoul, J. Racadot, and N. A. Baumann (1978), J. Neurol. Sci. 35, 147.PubMedGoogle Scholar
  92. Jellinger, K. (1978), Acta Neurochir. 42, 5.Google Scholar
  93. Jones, T. R., E. Ruoslahti, S. C. Schold, L. F. Eng, and D. D. Bigner (1980), J. Neuropath. Exptl. Neurol. 39, 365.Google Scholar
  94. Jordan, R. M., J. W. Kendall, J. L. Seaich, J. P. Allen, C. A. Paulsen, C. W. Kerber, and W. P. Vanderlaan (1976), Ann. Int. Med. 85, 49.PubMedGoogle Scholar
  95. Katzman, R., R. A. Fishman, and E. S. Goldensohn (1957), Neurol. 7, 853.Google Scholar
  96. Kaye, S. B., K. D. Bagshawe, T. J. McElwain, and M. J. Peckham (1979), Brit. J. Cancer 39, 217.PubMedGoogle Scholar
  97. Kennett, R. H., and F. Gilbert (1979), Science 203, 1120.PubMedGoogle Scholar
  98. Kennett, R. H., Z. Jonak, and K. B. Bechtol (1980), Prog. Cancer Res. Therapy 12, 209.Google Scholar
  99. Kepes, J. J., S. S. Rengachary, and S. H. Lee (1979a), Acta Neuropath. 47, 99.PubMedGoogle Scholar
  100. Kepes, J. J., L. J. Rubinstein, and L. F. Eng (1979b), Cancer 44, 1839.PubMedGoogle Scholar
  101. Kido, D. K., B. J. Dyce, B.J. Haverback, and C. L. Rumbaugh (1976), Bull. L. A. Neurol. Soc. 41, 47.Google Scholar
  102. Kimelberg, H. K., S. Narumi, S. Biddlecome, and R. S. Bourke (1977a), in Dynamic Properties ofGlia Cells (E. Schoffeniels, G. Franck, L. Hertz, and D. B. Tower, eds.), Pergamon, Oxford, pp. 347–358.Google Scholar
  103. Kimelberg, H. K., S. Narumi, S. Biddlecome, and R. S. Bourke (1977b), Trans. Am. Soc. Neurochem. 8, 89.Google Scholar
  104. Kleerekoper, M., R. A. Donald, and S. Posen (1972), Lancet 1, 74.PubMedGoogle Scholar
  105. Kleihues, P., and D. D. Bigner (1981), in The Molecular Basis of Neuropathology (R. H. S. Thompson and A. N. Davison, eds.), in press.Google Scholar
  106. Köhler, G., and C. Milstein (1975), Nature 256, 495.PubMedGoogle Scholar
  107. Köhler, G., and C. Milstein (1976), Eur. J. Immunol. 6, 511.PubMedGoogle Scholar
  108. Koprowski, H., Z. Steplewski, D. Herlyn, and M. Herlyn (1978), Proc. Natl. Acad. Sci. USA 75, 3405.PubMedGoogle Scholar
  109. Kumanishi, T., F. Ikuta, and T. Yamamoto (1970), Acta Neuropath. 16, 220.PubMedGoogle Scholar
  110. Kurihara, T., and Y. Tsukada (1967), J. Neurochem. 14, 1167.PubMedGoogle Scholar
  111. Kurihara, T., J. L. Nussbaum, and P. Mandel (1971), Life Sci. 10 (11), 421.Google Scholar
  112. Kurihara, T., S. Kawakami, K. Ueki, and Y. Takahashi (1974), J. Neurochem. 22, 1143.PubMedGoogle Scholar
  113. Lebherz, H. G., and W. J. Rutter (1969), Biochem. 8, 109.Google Scholar
  114. Levvy, G. A., and J. Conchie (1966), in Glucuronic Acid Free and Combined (G. J. Dutton, ed.), Academic Press, New York, pp. 301–364.Google Scholar
  115. Liem, R. K. H., and M. L. Shelanski (1978), Brain Res. 145, 196.PubMedGoogle Scholar
  116. Linfoot, J. A., J. F. Garcia, W. Wei, R. Fink, R. Sarin, J. L. Born, and J. H. Lawrence (1970), J. Clin. Endo. Metab. 31, 230.Google Scholar
  117. Login, I. S., and R. M. MacLeod (1977), Brain Res. 132, 477.PubMedGoogle Scholar
  118. Mandel, P., G. Roussel, J.-P. Delaunoy, and J.-L. Nussbaum (1977), in Dynamic Properties of Glia Cells (E. Schoffeniels, G. Franck, L. Hertz, and D. B. Tower, eds.) Pergamon, Oxford, pp. 267–274.Google Scholar
  119. Mann, S. H., N. DePasquale, and R. Paterson (1960), Neurol. 10, 381.Google Scholar
  120. Marangos, P. J., F. K. Goodwin, A. Parma, C. Lauter, and E. Trams (1978a), Brain Res. 145, 49.PubMedGoogle Scholar
  121. Marangos, P. J., A. M. Parma, and F. K. Goodwin (1978b), J. Neurochem. 39, 727.Google Scholar
  122. Martinez-Hernandez, A., K. P. Bell, and M. D. Norenberg (1977), Science 195, 1356.PubMedGoogle Scholar
  123. Marton, L. J., G. S. Gordon, M. Barker, C. B. Wilson, and W. Lubich (1973), Arch. Neurol. 28, 137.PubMedGoogle Scholar
  124. Marton, L. J., O. Heby, and C. B. Wilson (1974a), Int. J. Cancer 14, 731.PubMedGoogle Scholar
  125. Marton, L. J., O. Heby, C. B. Wilson, and P. L. Y. Lee (1974b), FEBS Letters 46, 305.PubMedGoogle Scholar
  126. Marton, L. J., O. Heby, V. A. Levin, W. P. Lubich, D. C. Crafts, and C. B. Wilson (1976), Cancer Res. 36, 973.PubMedGoogle Scholar
  127. Marton, L. J., M. S. Edwards, V. A. Levin, W. P. Lubich, and C. B. Wilson (1979), Cancer Res. 39, 993.PubMedGoogle Scholar
  128. Mason, D. Y., and P. Roberts-Thomson (1974), Lancet 2, 952.PubMedGoogle Scholar
  129. McDermott, J. R., and A. R. Smith (1978), J. Neurochem. 30, 1637.PubMedGoogle Scholar
  130. McGinnis, J. F., and J. de Vellis (1977), Arch. Biochem. Biophys. 179, 682.PubMedGoogle Scholar
  131. Mellick, R. S., and R. L. Bassett (1964), Lancet 1, 904.PubMedGoogle Scholar
  132. Miyazaki, M. (1958), J. Nerv. Ment. Dis. 126, 169.PubMedGoogle Scholar
  133. Moore, B. W. (1965), Biochem. Biophys. Res. Comm. 19, 739.PubMedGoogle Scholar
  134. Moore, B. W., and D. J. MacGregor (1965), J. Biol. Chem. 240, 1647.PubMedGoogle Scholar
  135. Moore, B. W., and V. J. Perez (1968), in Physiological and Biochemical Aspects of Neurons in Integration (F. D. Carlson, ed.), Prentice-Hall, Englewood Cliffs, New Jersey, pp. 343–359.Google Scholar
  136. Mori, T., H. Mogami, P. F. Benda, and W. H. Sweet (1968), Neurol. Med. Chir. 10, 103.Google Scholar
  137. Mori, T., K. Morimoto, Y. Ushio, T. Hayakawa, and H. Mogami (1975a), Neurol. Med. Chir. 15, 23.Google Scholar
  138. Mori, T., K. Morimoto, Y. Ushio, and H. Mogami (1975b), Igaku-No-Ayumi 18, 16.Google Scholar
  139. Mori, T., K. Morimoto, T. Hayakawa, Y. Ushio, H. Mogami, and K. Sekiguchi (1978), Neurol. Med. Chir. 18, 25.Google Scholar
  140. Morrison, P., J. Edsall, and S. Miller (1948), J. Amer. Chem. Soc. 70, 3103.Google Scholar
  141. Moshly-Rosen, D., S. Fuchs, and Z. Eshhar (1979), FEBS Letters 106, 389.PubMedGoogle Scholar
  142. Myerson, R. M., J. K. Hurwitz, and T. Sail (1957), New Engl. J. Med. 257, 273.PubMedGoogle Scholar
  143. Newman, J., A. S. Josephson, A. Cacatian, and A. Tsang (1974), Lancet 2, 756.PubMedGoogle Scholar
  144. Niebroj-Dobosz, I., and L. Hetnarska (1969), Polish Med. J. 8, 451.Google Scholar
  145. Norenberg, M. D. (1979), J. Histochem. Cytochem. 27, 756.PubMedGoogle Scholar
  146. Norenberg, M. D., and A. Martinez-Hernandez (1979), Brain Res. 161, 303.PubMedGoogle Scholar
  147. Nørgaard-Pedersen, B., J. Lindholm, R. Albrechtsen, J. Arends, N. H. Diemer, and J. Rüshede (1978), Cancer 41, 2315.PubMedGoogle Scholar
  148. Nowell, P. C. (1976), Science 194, 23.PubMedGoogle Scholar
  149. Orly, J., and G. Sato (1979), Cell 17, 295.PubMedGoogle Scholar
  150. Paoletti, P., F. A. Vandenheuvel, R. Fumagalli, and R. Paoletti (1969), Neurol. 19, 190.Google Scholar
  151. Paoletti, P., R. Fumagalli, E. Grossi-Paoletti (1972), in The Experimental Biology of Brain Tumors (W. M. Kirsch, E. Grossi-Paoletti, and P. Paoletti, eds.), Charles C Thomas, Springfield, Illinois, pp. 457–479.Google Scholar
  152. Paoletti, P., R. Fumagalli, F. J. Weiss, and S. Pezzotta (1977), Surg. Neurol. 8, 399.PubMedGoogle Scholar
  153. Parker, K. K., M. D. Norenberg, and A. Vernadakis (1980), Science 208, 179.PubMedGoogle Scholar
  154. Penhoet, E., T. Rajkumar, and W. J. Rutter (1966), Proc. Natl. Acad. Sci. USA 56, 1275.PubMedGoogle Scholar
  155. Perez, V. J., J. W. Olney, T. J. Cicero, B. W. Moore, and B. A. Bahn (1970), J. Neurochem. 17, 511.PubMedGoogle Scholar
  156. Pfeiffer, S. E., and W. Wechsler (1972), Proc. Natl. Acad. Sci. USA 69, 2885.PubMedGoogle Scholar
  157. Pfeiffer, S. E., P. L. Kornblith, H. L. Cares, J. Seals, and L. Levine (1972), Brain Res. 41, 187.PubMedGoogle Scholar
  158. Pfeiffer, S. E., N. Sundarraj, G. Dawson, and P. L. Kornblith (1979), Acta Neuropath. 47, 27.PubMedGoogle Scholar
  159. Pickel, V. M., D. J. Reis, P. J. Marangos, and C. Zomzely-Neurath (1976), Brain Res. 105, 184.PubMedGoogle Scholar
  160. Poduslo, S. E. (1975), J. Neurochem. 24, 647.PubMedGoogle Scholar
  161. Posner, J. B., D. D. Bigner, W. Shapiro, G. J. D’Angio, and M. D. Walker (1979), National Institute of Neurological and Communicative Disorders and Stroke, NIH publication, p. 224.Google Scholar
  162. Rabow, L., and K. Kristensson (1977), Acta Neurochir. 36, 71.Google Scholar
  163. Ransohoff, J., and J. Weiss (1977), Natl. Cancer Inst. Monographs 46, 119.Google Scholar
  164. Rasmussen, S., E. Bock, K. Warecka, and G. Althage (1980), Brit. J. Cancer 41, 113.PubMedGoogle Scholar
  165. Reitamo, S., and M. Klockars (1976), Acta Med. Scand. 199, 321.PubMedGoogle Scholar
  166. Rueger, D. C., D. Dahl, and A. Bignami (1978a), Brain Res. 153, 188.PubMedGoogle Scholar
  167. Rueger, D. C., D. Dahl, and A. Bignami (1978b), Anal. Biochem. 89, 360.PubMedGoogle Scholar
  168. Ruoslahti, E., A. Vaheri, P. Kuusela, and E. Linder (1973), Biochim. Biophys. Acta 322, 352.PubMedGoogle Scholar
  169. Rushworth, A. G. J., A. H. Orr, and K. D. Bagshawe (1968), Brit. J. Cancer 22, 253.PubMedGoogle Scholar
  170. Russell, D. H. (1971), Nature New Biol. 233, 144.PubMedGoogle Scholar
  171. Russell, D. H. (1973), Life Sci. 13, 1635.PubMedGoogle Scholar
  172. Russell, D. H., and B. C. M. Durie (1978), Progress in Cancer Research and Therapy, Vol. 8, Raven, New York, p. 178.Google Scholar
  173. Russell, D. H., C. C. Levy, S. C. Schimpff, and I. A. Hawk (1971), Cancer Res. 31, 1555.PubMedGoogle Scholar
  174. Russell, D. S., and L. J. Rubinstein (1977), Pathology of Tumours of the Nervous System, Williams and Wilkins, Baltimore, p. 448.Google Scholar
  175. Sapirstein, V. S., and M. B. Lees (1977), Trans. Am. Soc. Neurochem. 8, 245.Google Scholar
  176. Sato, S., T. Sugimura, T. C. Chien, and K. Takakura (1971), Cancer 27, 223.PubMedGoogle Scholar
  177. Schachner, M., G. Schoonmaker, and H. O. Hynes (1978), Brain Res. 158, 149.PubMedGoogle Scholar
  178. Schaub, C., M. T. Bluet-Pajot, G. Szikla, C. Lornet, and J. Talairach (1977), J. Neurol. Sci. 31, 123.PubMedGoogle Scholar
  179. Schiffer, D., A. Fabiani, A. Cognazzo, and G. F. Monticone (1969), Acta Neuropath. 13, 91.PubMedGoogle Scholar
  180. Schmechal, D., P. J. Marangos, A. P. Zis, M. Brightman, and F. K. Goodwin (1978), Science 199, 313.Google Scholar
  181. Schold, S. C., and D. E. Bullard (1980), in Neurobiology of Cerebrospinal Fluid (J. N. Wood, ed.), Plenum, New York, pp. 549–559.Google Scholar
  182. Schold, S. C., W. R. Wasserstrom, M. Fleisher, M. K. Schwartz, and J. B. Posner (1980), Ann. Neurol. 8, 597.PubMedGoogle Scholar
  183. Schroeder, L. L., J. C. Johnson, and W. B. Malarkey (1976), J. Clin. E ndo. Metab. 43, 1255.Google Scholar
  184. Schubert, D., S. Heineman, W. Carlisle, H. Tarikas, B. Kimes, J. Patrick, J. H. Steinbach, W. Culp, and B. L. Brandt (1974), Nature 249, 224.PubMedGoogle Scholar
  185. Seidenfeld, J., and L. J. Marton (1979), J. Natl. Cancer Inst. 63, 919.PubMedGoogle Scholar
  186. Sensenbrenner, M., G. Moonen, J. P. Delaunoy, E. Bock, P. Poindron, and P. Mandel (1977), Trans. Am. Soc. Neurochem. 8, 82.Google Scholar
  187. Shapiro, W. R., G. A. Basler, N. L. Chernik, and J. B. Posner (1979) J. Natl. Cancer Inst. 62, 447.PubMedGoogle Scholar
  188. Sheffield, W. D., and S. U. Kim (1977), Brain Res. 120, 193.PubMedGoogle Scholar
  189. Shinomiya, Y., S. Toya, T. Iwata, and Y. Hosoda (1979), Child’s Brain 5, 450.PubMedGoogle Scholar
  190. Shively, J. E., and C. W. Todd (1978), Scand. J. Immunol. Suppl. 6, 91.Google Scholar
  191. Sims, N. R., and P. R. Carnegie (1976), J. Neurochem. 27, 769.PubMedGoogle Scholar
  192. Sims, N. R., L. B. Horvath, and P. R. Carnegie (1979), Biochem. J. 181, 367.PubMedGoogle Scholar
  193. Singer, I. (1979), Cell 16, 675.PubMedGoogle Scholar
  194. Snitzer, L. S., and E. C. McKinney (1976), Proc. Amer. Assoc. Cancer Res. Amer. Soc. Clin. Oncol. 17, 249.Google Scholar
  195. Snitzer, L. S., E. C. McKinney, F. Tejada, M. M. Sigel, N. L. Rosomoff, and C. G. Zubrod (1975), New Engl. J. Med. 293, 1101.PubMedGoogle Scholar
  196. Spicer, S. S., P. J. Stoward, and R. E. Tashian (1979), J. Histochem. Cytochem. 27, 820.PubMedGoogle Scholar
  197. Sudo, T., M. Kikuno, and T. Kurihara (1972), Biochim. Biophys. Acta 255, 640.PubMedGoogle Scholar
  198. Sugimura, T., S. Sato, S. Kawabe, N. Suzuki, T. C. Chein, and K. Takakura (1969), Nature 222, 1070.PubMedGoogle Scholar
  199. Sundarraj, N., M. Schachner, and S. E. Pfeiffer (1975), Proc. Natl. Acad. Sci. USA 72, 1927.PubMedGoogle Scholar
  200. Terabayashi, T. (1976) Neurol. Med. Chir. 16, 43.Google Scholar
  201. Thomas, F. J., H. M. Lloyd, and M. J. Thomas (1972), J. Clin. Path. 25, 774.PubMedGoogle Scholar
  202. Trotter, J. L., B. Huss, W. P. Blank, K. O’Connell, S. Hagan, W. T. Shearer, and H. C. Agrawal (1978), Trans. Am. Soc. Neurochem. 9, 59.Google Scholar
  203. Vaheri, A., E., Ruoslahti, B. Westermark, and J. Ponten (1976), J. Exptl. Med. 143, 64.Google Scholar
  204. Vaitukaitis, J. L., G. D. Braunstein, and G. T. Ross (1972), Am. J. Obstet. Gynecol. 113, 751.PubMedGoogle Scholar
  205. van der Meulen, J. D. M., H. J. Houthoff, and E. J. Ebels (1978), Neuropath. Appl. Neurobiol. 4, 177.Google Scholar
  206. Velasco, M. E., D. Dahl, U. Roessman, and P. Gambetti (1980), Cancer 45, 484.PubMedGoogle Scholar
  207. Vick, N. A., J. D. Khandekar, and D. D. Bigner (1977), Arch. Neurol. 34, 523.PubMedGoogle Scholar
  208. Volpe, J. J., K. Fujimoto, J. C. Marasa, and H. C. Agrawal (1975), Biochem. J. 152, 701.PubMedGoogle Scholar
  209. Vraa-Jensen, J., M. M. Herman, L. J. Rubinstein, and A. Bignami (1976), Neuropath. Appl. Neurobiol. 2, 349.Google Scholar
  210. Warecka, K. (1975), J. Neuro. Sci. 26, 511.Google Scholar
  211. Warecka, K., and H. Bauer (1967), J. Neurochem. 14, 783.PubMedGoogle Scholar
  212. Warecka, K., H. J. Moller, H.-M. Vogel, and I. Tripatzis (1972), J. Neurochem. 19, 719.PubMedGoogle Scholar
  213. Weiler, C. T., B. Nystrom, and A. Hamberger (1979), Brain Res. 160, 539.PubMedGoogle Scholar
  214. Weiss, J. F., J. Ransohoff, and H. J. Kayden (1972), Neurol. 22, 187.Google Scholar
  215. Whitaker, J. N., R. P. Lisak, R. M. Bashir, O. H. Fitch, J. M. Seyer, R. Krance, J. A. Lawrence, L. T. Ch’ien, and P. O’Sullivan (1980), Ann. Neurol. 7, 58.PubMedGoogle Scholar
  216. Wikstrand, C. J., and D. D. Bigner (1980), Amer. J. Path. 98, 515.Google Scholar
  217. Wollemann, M. (1974), Biochemistry of Brain Tumors, University Park Press, Baltimore, p. 194.Google Scholar
  218. Wright, A. D., M. S. McLachlan, F. H. Doyle, and T. Fraser (1969), Brit. Med. J. 4, 582.PubMedGoogle Scholar
  219. Wroblewski, F. (1959), Cancer 12, 27.PubMedGoogle Scholar
  220. Wroblewski, F., B. Decker, and R. Wroblewski (1957), Amer. J. Clin. Path. 28, 269.Google Scholar
  221. Yamada, K., and K. Olden (1978), Nature 275, 179.PubMedGoogle Scholar
  222. Yamada, K., S. Yamada, and I. Pastan (1976), Proc. Natl. Acad. Sci. USA 73, 1217.PubMedGoogle Scholar
  223. Yap, B.-S., H.-Y. Yap, R. S. Benjamin, G. P. Bodey, and E. J. Freidreich (1978), Proc. Amer. Assoc. Cancer Res. Amer. Soc. Clin. Oncol. 19, 98.Google Scholar
  224. Zanetta, J. P., P. Benda, G. Gombos, and I. G. Morgan (1972), J. Neurochem. 19, 881.PubMedGoogle Scholar

References

  1. Bourdon, M. A., C. J. Wikstrand, C. N. Pegram, and D. D. Bigner (1981), Fed. Proc. 40, 821.Google Scholar
  2. Carrel, S., R. S. Accolla, A. L. Carmagnola, and J. P. Mach (1980), Cancer Res. 40, 2523.PubMedGoogle Scholar
  3. Dippold, W. G., K. O. Lloyd, L. T. C. Li, H. Ideka, H. F. Oettgen, and L. J. Old (1980), Proc. Natl. Acad. Sci. USA 77, 6114PubMedGoogle Scholar
  4. Herlyn, M., W. H. Clark, M. J. Mastrangelo, D. Guerry, D. E. Elder, D. La Rossa, R. Hamilton, E. Bondi, R. Tuthill, Z. Steplewski, and H. Koprowski (1980), Cancer Res. 401, 3602.Google Scholar
  5. Imai, K., A. K. Ng, and S. Ferrone (1981), J. Natl. Cancer Inst. 66, 489PubMedGoogle Scholar
  6. Liao, S. K., B. J. Clarke, B. C. Gallie, and P. B. Dent (1981), Eur. J. Cancer, in press.Google Scholar
  7. Schnegg, J. F., A. C. Diserenns, S. Carrel, R. S. Accolla, and N. de Triboet (1981), Cancer Res. 41, 1290.Google Scholar
  8. Seeger, R. C. (1981), in Hybridomas in Cancer Diagnosis (M. S. Mitchell and H. F. Oettgen, eds.), Raven Press, NY.Google Scholar
  9. Wikstrand, C. J., C. N. Pegram, M. A. Bourdon, and D. D. Bigner (1981), Proc. Amer. Assoc. Cancer Res. 22, 304.Google Scholar

Copyright information

© HUMANA Press Inc. 1982

Authors and Affiliations

  • Trevor R. Jones
    • 1
  • Darell D. Bigner
    • 1
  1. 1.Department of PathologyDuke University Medical CenterDurhamUSA

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