Cell Surface Antigens on Normal and Neoplastic Human Lymphoid Cells

  • Robert Fox
  • Stephen Baird
  • Patrick Kung
  • Ron Levy
  • Ivor Royston
Part of the Contemporary Biomedicine book series (CB, volume 2)


In the last 20 years, we have learned a great deal about the structure and function of the normal lymphoid system. In parallel, we have also learned much more about tumors of the lymphoid system. Frequently, information developed through experiments on lymphomas has been helpful to our understanding of normal lymphoid cells and vice versa. The irresistible tendency to draw parallels between the normal and malignant lymphoid system is illustrated by the current ways of classifying lymphomas. It is postulated that different types of malignant lymphoid cells reflect a particular stage of development of a normal lymphoid cell. For example, not only do we now classify some lymphomas as B cell-derived, but also attempt an even further refinement and describe the surface markers of the malignant cells as characteristic of pre B cells, mature B cells, or plasma cells (Greaves and Janossy, 1978; Greaves et al., 1980.)


Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Peripheral Blood Lymphocyte Lymphoid Cell Lymphocyte Subset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abramson, C., J. Kersey, and T. LeBien (1981), J. Immunol 126, 83.PubMedGoogle Scholar
  2. Ades, E., R. Zwernor, R. Acton, and C. Balch (1980), J. Exptl. Med 151, 400.Google Scholar
  3. Aisenberg, A., and J. Long (1975), Am. J. Med 58, 300.PubMedGoogle Scholar
  4. Anderson, J., and R. Metzgar (1978), J. Immunol 120, 262.PubMedGoogle Scholar
  5. Ault, K., and T. Springer (1981), J. Immunol 126, 359.PubMedGoogle Scholar
  6. Balch, C., P. Dourgert, L. Volger, E. Ades, and S. Ferrone (1978), J. Immunol 121, 232.Google Scholar
  7. Balch, H., E. Ades, M. Loken, and S. Shore (1980), J. Immunol 124, 1845.PubMedGoogle Scholar
  8. Barclay, A., M. Letarte-Muirhead, A. Williams, and R. Foulker (1976), Nature 263, 563.PubMedGoogle Scholar
  9. Bentwich, Z., S. Douglas, E. Skutelsky, and H. Kunkel (1973), J. Exptl. Med 137, 1532.Google Scholar
  10. Billing, R., and P. Terasaki (1974), J. Natl. Cancer Inst 53, 1635.PubMedGoogle Scholar
  11. Borella, L., and L. Sen (1973), J. Immunol III, 1257.Google Scholar
  12. Bowman, P., S. Melvin, and A. Mauer (1980), Adv. Int. Med 25, 391.Google Scholar
  13. Bradstock, K., G. Janossy, M. Bollum, andC. Milstein (1980a), Nature 284 (in press).Google Scholar
  14. Bradstock, K., G. Janossy, G. Pizzolo, V. Hoffmand, A. McMichael, J. Pilch, C. Milstein, P. Beverly, and F. Bollum (1980b), J. Natl. Cancer Inst 65, 33.PubMedGoogle Scholar
  15. Breard, J., E. Reinherz, P. Kung, G. Goldstein, and S. Schlossman (1980), J. Immunol 124, 1943.PubMedGoogle Scholar
  16. Broder, S., and T. Waldmann (1978), New Engl. J. Med 299, 1281.PubMedGoogle Scholar
  17. Brooks, H., I. Beckman, and H. Zola (1980), Clin. Exptl. Immunol 39, 477.Google Scholar
  18. Brouet, J., and M. Seligmann (1978), Cancer 42, 817.PubMedGoogle Scholar
  19. Brown, G., M. Greaves, T. Lister, and N. Rapson (1974), Lancet 2, 753.PubMedGoogle Scholar
  20. Cantor, H., F. Shen, and E. Boyse (1976), J. Exptl. Med 143, 1391.Google Scholar
  21. Checkik, B., M. Percy, and E. Gelfand (1978), J. Natl. Cancer Inst 60, 69.Google Scholar
  22. Checkik, B., J. Rao, M. Greaves, and V. Hoffbrand (1980), Leukemia Res. 4, 343.Google Scholar
  23. Claman, H., and E. Chaperon (1969), Transpl. Rev 1, 92.Google Scholar
  24. Cooper, M. (1979), J. Exptl. Med 150, 792.Google Scholar
  25. Cordier, G., C. Samarut, J. Brochier, and J. P. Revillard (1976), Scand. J.Immunol 5, 233 Google Scholar
  26. Dickler, H., and H. Kunkel (1972), J. Exptl. Med 136, 191.Google Scholar
  27. Eisenbarth, G., J. Haynes, A. Schroer, and A. Fauci (1980), J. Immunol 124, 1237.PubMedGoogle Scholar
  28. Engleman, E., R. Fox, R. Warnke, and R. Levy (1981), Proc. Natl. Acad. Sci (in press).Google Scholar
  29. Evans, R., J. Breard, H. Lazarus, S. Schlossman, andL. Chess (1977), J. Exptl. Med 145, 221.Google Scholar
  30. Evans, R., T. Faldetta, R. Humphrey, D. Pratt, E. Yunis, and S. Schlossman (1978), J. Exptl. Med 148, 1440.Google Scholar
  31. Ferrarini, M., T. Hoffman, S. Fu, R. Winchester, and H. Kunkel (1977), J. Immunol 199, 1525.Google Scholar
  32. Fox, R., and I. Weissman (1979), J. Immunol 122, 1697.PubMedGoogle Scholar
  33. Friedman, H., J. Brochier, and J. Revillard (1976), Immunol. 31, 759.Google Scholar
  34. Gonzales, A., and H. Spiegelberg (1977), J. Clin. Inv 59, 616.Google Scholar
  35. Greaves, M., G. Brown, N. Rapson, and T. Lister (1975), Clin. Immunol. Immunopath 4, 67.Google Scholar
  36. Greaves, M., and G. Janossy (1978), Biochem. Biophys. Acta 516, 193.PubMedGoogle Scholar
  37. Greaves, M., W. Verbi, L. Vogler, M. Cooper, and R. Ellis (1980), Leukemia Res. 3, 353.Google Scholar
  38. Hanaumi, K., T. Abo, and K. Kumagi (1976), Nature 259, 124.PubMedGoogle Scholar
  39. Hansen, J., P. Martin, and R. Nowinski (1980), Immunogenetics 10, 247.Google Scholar
  40. Haynes, B., J. Schooley, C. Grouse, R. Payling, R. Dolin, and A. Fauci (1979), J. Immunol 122, 699.PubMedGoogle Scholar
  41. Hay ward, A., L. Lay ward, P. Lydyard, L. Moretta, M. Dagg, and A. Lawton (1978), J. Immunol 121, 1.PubMedGoogle Scholar
  42. Hoessli, D., C. Bron, and R. Pink (1980), Nature 283, 576.PubMedGoogle Scholar
  43. Jaffee, E., E. Shevach, M. Frank, C. Breard, and I. Green (1974), New Engl. J. Med 290, 813.Google Scholar
  44. Janossy, G., F. Bollum, A. McMichael, N. Rapson, and M. Greaves (1979), J. Immunol 123, 1525.PubMedGoogle Scholar
  45. Janossy, G., N. Tidman, E. Papageorgiou, P. Kung, and G. Goldstein (1981), J. Immunol. 126, 1608.PubMedGoogle Scholar
  46. Jondal, M., G. Holm, and H. Wigzell (1972), J. Exptl. Med 136, 207.Google Scholar
  47. Kamoun, P., Martin, P., Hansen, J., Brown, M., Siadek, A. and Nowinski, R. (1981), J. Exp. Med 153, 207PubMedGoogle Scholar
  48. Katz, D. (1977), Lymphoid Differentiation, Recognition and Regulation. Academic Press, New York, pp. 1 - 119.Google Scholar
  49. Katz, D., and B. Benacerraf (1972), Adv. Immunol 15, 1.PubMedGoogle Scholar
  50. Kersey, J., T. LeBien, C. Abramson, R. Newman, R. Sutherland, and M. Greaves (1981), J. Exptl. Med (in press).Google Scholar
  51. Ko, H., S. Fu, R. Winchester, D. Ya, and H. Kunkel (1979), J. Exptl. Med 150, 246.Google Scholar
  52. Kohler, G., and C. Milstein (1975), Nature 256, 495. Kumagi, K., T. Abo, T. Sekizawa, and M. Sasaki (1975), J. Immunol 115, 982.Google Scholar
  53. Kung, P., G. Goldstein, E. Reinherz, and S. Schlossman (1979), Science 206, 347.PubMedGoogle Scholar
  54. Kung, P., and G. Goldstein (1980), Vox Sanguinis 39, 121.PubMedGoogle Scholar
  55. Huber, H., S. Douglas, and H. Fudenberg (1969), Immunology 17, 7.PubMedGoogle Scholar
  56. Lampson, L., and R. Levy (1980), J. Immunol 125, 293.PubMedGoogle Scholar
  57. Le Bien, T., and J. Kersey (1980), J. Immunol 125, 2208.Google Scholar
  58. Ledbetter, J., R. Evans, and L. Herzenberg (1981), J. Exptl. Med 153, 310.Google Scholar
  59. Ledbetter, J., J. Goding, T. Tsu, and L. Herzenberg (1979), Immunogenetics 8, 347.Google Scholar
  60. Ledbetter, J. and L. Herzenberg (1980), Immunol. Rev 47, 63.Google Scholar
  61. Levy, R., J. Dilley, R. Fox, and P. Warnke (1979), Proc. Natl. Acad. Sci 76, 6552.PubMedGoogle Scholar
  62. Limatibul, S., A. Shore, H. Dosch, and E. Gelfund (1978), Clin. Exptl. Immunol 33, 503.Google Scholar
  63. Loken, M., and L. Herzenberg (1975), Ann. NY Acad. Sci 254, 163.PubMedGoogle Scholar
  64. Lum, L., M. Keren, W. Strober, and R. Bloese (1979), J. Immuno 122, 65.Google Scholar
  65. Mackler, B., E. Richie, and T. Swate (1980), Clin. Immunol. Immunolpath 15, 238.Google Scholar
  66. Mann, D., G. Rogentine, R. Halterman, and B. Leventhal (1971), Science 1974, 1136.Google Scholar
  67. Mann, R., E. Jaffe, and C. Breard (1979), Amer. J. Pathol 94, 105.Google Scholar
  68. McMichael, A., J. Pilch, G. Golfre, D. Mason, and C. Milstein (1979), Eur. J. Immunol 9, 205.PubMedGoogle Scholar
  69. Merrill, J., G. Biberfeld, G. Kolmodin, S. Landin, and E. Norrby (1980), J. Immunol 124, 2758.PubMedGoogle Scholar
  70. Mingari, M., L. Moretta, A. Moretta, M. Ferrarini, and J. Preud’homme (1978), J. Immunol 121, 767.PubMedGoogle Scholar
  71. Minowada, J., T. Ohnuma, and G. Moore (1972), J. Natl. Cancer Inst 49, 891.PubMedGoogle Scholar
  72. Mohanakumar, T., and R. Roney (1978), Clin. Haem 7, 363.Google Scholar
  73. Moretta, L., M. Ferranini, C. Mingari, A. Moretta, and S. Webb (1976), J. Immunol 117, 2171.PubMedGoogle Scholar
  74. Moretta, L., S. Webb, P. Grossi, P. Lydyard, and M. Cooper (1977), J. Exptl. Med 146, 184.Google Scholar
  75. Moriya, N., T. Nagaoki, N. Okuda, and N. Taniguchi (1979), J. Immunol 123, 1795.PubMedGoogle Scholar
  76. Nadler, L., E. Reinherz, H. Weinstein, C. Orsi, and S. Schlossman (1980a), Blood 55, 806.PubMedGoogle Scholar
  77. Nadler, L., J. Ritz, R. Handy, J. Pesando, and S. Schlossman (1981), J. Clin. Invest 67, 134.PubMedGoogle Scholar
  78. Nadler, L., P. Stashenko, R. Hardy, and S. Schlossman (1980b), J. Immunol 125, 570.PubMedGoogle Scholar
  79. Nakahara, K., T. Ohashi, T. Oda, T. Hirano, M. Kasai, K. Okumura, and T. Tada (1980), New Engl. J. Med 302, 675.Google Scholar
  80. Niaudet, P., and M. Greaves (1980), J. Immunol 124, 1203.PubMedGoogle Scholar
  81. Niaudet, P., M. Greaves, and D. Horwitz (1979), Scand. J. Immunol 9, 387.PubMedGoogle Scholar
  82. Noorloos, A., H. Pegels, R. Oors, J. Wilberbusch, T. Vroom, R. Goudsint, W. Zeijlemaker, A. Bornee, and C. Melief (1980), N. Engl. J. Med 320, 933.Google Scholar
  83. Omary, M., I. Trowbridge, and J. Minowada (1980), Nature 286, 888.PubMedGoogle Scholar
  84. Owen, R., G. Bernier, and M. Farger (1976), Immunochemistry 13, 129.PubMedGoogle Scholar
  85. Ozer, H., A. J. Strelkauskas, R. T. Callery, and S. F. Schlossman (1979), Eur. J. Immunol 9, 112.PubMedGoogle Scholar
  86. Pellegrino, M., S. Ferrone, M. Dierich, and R. Reisfeld (1975), Clin. Immuno. Immunopath 3, 324.Google Scholar
  87. Pesando, J., J. Ritz, H. Levine, C. Terhorst, H. Lazarus, and S. Schlossman (1980), J. Immunol 124, 2794.PubMedGoogle Scholar
  88. Pichler, W., and S. Broder (1978), J. Immunol 121, 887.PubMedGoogle Scholar
  89. Pratt, D., S. Schlossman, and J. Strominger (1980), J. Immunol 124, 1449.PubMedGoogle Scholar
  90. Preud’homme, J., M. Klein, S. Labaume, and M. Seligman (1977), Eur. J. Immunol 1, 840.Google Scholar
  91. Ransohof, D., and A. Feinstein (1978), N. Engl. J. Med. 299, 926. Rappaport, H. (1966), in Atlas of Tumor Pathology, sect. Ill, fasc. 8, Armed Forces Institute of Pathology, Washington, D.C.Google Scholar
  92. Reinherz, E., P. Kung, G. Goldstein, and S. Schlossman (1979a), J. Immunol 123, 1312.PubMedGoogle Scholar
  93. Reinherz, E., P. Kung, G. Goldstein, and S. Schlossman (1979f), Proc. Natl. Acad. Sci 76, 4061.PubMedGoogle Scholar
  94. Reinherz, E., P. Kung, G. Goldstein, and S. Schlossman (1979g), J. Immunol. 2894.Google Scholar
  95. Reinherz, E., P. Kung, G. Goldstein, and S. Schlossman (1980b), J. Immunol. 1301.Google Scholar
  96. Reinherz, E., P. Kung, G. Goldstein, R. Levy, and S. Schlossman (1980a), Proc. Natl. Acad. Sci 77, 1588.PubMedGoogle Scholar
  97. Reinherz, E., P. Kung, J. Resando, J. Ritz, G. Goldstein, and S. Schlossman (1979c), J. Exptl. Med 150, 1472.Google Scholar
  98. Reinherz, E., L. Moretta, M. Roper, J. Breard, M. Mingari, M. Cooper, and S. Schlossman (1980d), J. Exptl. Med 151, 969.Google Scholar
  99. Reinherz, E., L. Nadler, D. Rosenthal, W. Moloney, and S. Schlossman (1979d), Blood, 53, 1066.PubMedGoogle Scholar
  100. Reinherz, E., L. Nadler, S. Sallon, and S. Schlossman (1979b), J. Clin. Invest 64, 392.PubMedGoogle Scholar
  101. Reinherz, E., R. Parkman, J. Rappaport, F. Rosen, and S. Schlossman (1979e), N. Engl. J. Med 300, 1061.PubMedGoogle Scholar
  102. Reinherz, E., and S. Schlossman (1980c), Cell 19, 821.PubMedGoogle Scholar
  103. Reinherz, E., and S. Schlossman (1980e), Cancer Treatment Reports Google Scholar
  104. Ritz, J., J. Pesando, J. Notis-McConarty, H. Lazarus, and S. Schlossman (1980), Nature 283, 583.PubMedGoogle Scholar
  105. Rowe, D., and J. Fahey (1965), J. Exptl. Med 121, 171.Google Scholar
  106. Royston, I., J. Majda, S. Baird, G. Yamamoto, B. Meserve, C. Ivor, and J. Griffiths (1980a), J. Immunol 125, 725.PubMedGoogle Scholar
  107. Royston, I., J. Majda, G. Yamamoto, and S. Baird (1980b), Proc. 28th Colloquium, Pergamon Press, London, 1980. Sachs, L. (1978), Nature 274, 535.Google Scholar
  108. Sallan, S., J. Ritz, J. Pesando, R. Geller, C. O’Brien, S. Hitchcock, F. Coral, and S. Schlossman (1980), Blood 55, 395.PubMedGoogle Scholar
  109. Salmon, S., and M. Seligman (1974), Lancet 2, 1230.PubMedGoogle Scholar
  110. Schuster, D., B. Bongiovani, D. Pierson, D. Wond, and A. Levinson (1980), J. Immunol. 124, 1662. Seligman, M., J. Preud’homme, and J. Brovet (1973), Transplant. Rev. 16, 83.Google Scholar
  111. Sell, S. (1980), Cancer Markers, Humana, Clifton, N.J. Shore, S. L., F. M. Melewicz, and D. S. Gordon (1977), J. Immunol 118, 558.Google Scholar
  112. Taub, R., M. Baker, and K. Madyastha (1980), 55, 294.Google Scholar
  113. Trowbridge, I., and M. Omary (1981), Proc. Nat. Acad. Sci (in press).Google Scholar
  114. Unanue, E., H. Grey, E. Rabellino, P. Campbell, and J. Schmidtke (1971), J. Exptl. Med 133, 1188.Google Scholar
  115. Van Boxel, J., W. Paul, W. Terry, and I. Green (1972), J. Immunol 109, 648.PubMedGoogle Scholar
  116. Van Wauwe, J., J. DeMey, and J. Goossens (1980), J. Immunol 124, 2708.PubMedGoogle Scholar
  117. Wang, C., R. Good, P. Ammirati, G. Dymbort, and R. Evans (1980), J. Exptl. Med 151, 1539.Google Scholar
  118. Warnke, R., and R. Levy (1978), N. Engl. J. Med 298, 481.PubMedGoogle Scholar
  119. Watanabe, K., and S. Hakomori (1976), J. Exptl. Med. 144, 644. Weiner, M., C. Bianoc, and V. Nussenzweig (1973), Blood 42, 939.Google Scholar
  120. Weissman, I., A. Warnke, E. Butcher, R. Rouse, and R. Levy (1978), Human Path. 9, 325.Google Scholar
  121. West, W. H., R. B. Boozer, and R. B. Herberman (1978), J. Immunol 120, 90.PubMedGoogle Scholar
  122. Winchester, R., and H. Kunkel (1980), Adv. Immunol 28, 221. Wybran, J., M. Carr, and H. Fudenberg (1973), Clin. Immunol. Immunopath. 1, 408.Google Scholar
  123. Wybran, J., and H. Fudenberg (1973), Clin. Immunol. Immunopath 52, 1026.Google Scholar
  124. Zipf, T., R. Fox, J. Dilley, and R. Levy (1981), Cancer Res. Treat. Rpts Google Scholar

Copyright information

© HUMANA Press Inc. 1982

Authors and Affiliations

  • Robert Fox
    • 1
  • Stephen Baird
    • 2
  • Patrick Kung
    • 3
  • Ron Levy
    • 4
  • Ivor Royston
    • 2
  1. 1.Department of Clinical ResearchScripps Clinic and Research FoundationLa JollaUSA
  2. 2.University of CaliforniaSan DiegoUSA
  3. 3.Ortho Pharmaceutical CorporationRaritanUSA
  4. 4.Stanford University Medical CenterStanfordUSA

Personalised recommendations