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Variation in Influenza Virus Genes

Epidemiological, Pathogenic, and Evolutionary Consequences
  • Frances I. Smith
  • Peter Palese
Chapter
Part of the The Viruses book series (VIRS)

Abstract

Influenza viruses can be classified into three types: A, B, and C. Strains of the same type share serologically cross-reactive matrix (M) proteins and nucleoproteins (NP), which are the major components of the virus. Recent technological advances have resulted in the cloning and sequencing of genes of many members of each type. The results indicate that the genetic information of influenza viruses is not static and that the amount and pattern of variation differs for the three types of influenza virus. The purpose of this chapter is to review the variation seen within the different types, with an emphasis on human influenza viruses. Also, we consider factors that may contribute to this variation and attempt to correlate the differences seen among the three types with differences in the biological properties and epidemiology of these viruses Finally, an attempt is made to compare variation of influenza viruses with that seen in other RNA viruses.

Keywords

Influenza Virus Human Influenza Equine Infectious Anemia Virus Live Attenuate Influenza Vaccine Human Influenza Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Frances I. Smith
    • 1
  • Peter Palese
    • 1
  1. 1.Department of MicrobiologyMount Sinai School of MedicineNew YorkUSA

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