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Effects of Xipamide on Transmembranary Potassium Movements and Prostacyclin Production

  • J. Diez
  • I. Colina
  • J. Quiroga
  • R. Diaz-Tejeiro
  • L. Yap
  • F. Maduell
  • P. Errasti
  • A. Purroy
  • J. Prieto
Chapter
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Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Several observations suggest a possible interaction between ion transport mechanisms and the arachidonic acid cascade in the natriuretic and in the antihypertensive effects of diuretics(1). Moreover, several studies have established that some diuretic drugs may act on the arachidonic acid cascade(2). In fact, it has been recently reported that the modification of K+ transmembrane gradient by some diuretic drugs may stimulate the generation of prostacyclin, PGI2,(3), Xipamide, X, is a sulfonamide type drug with diuretic and antihypertensive effects but whose mechanism of action remains unknown(4). We, thus, have investigated whether X does modify transmembranary K+ movements and PGI2 production.

Keywords

Antihypertensive Effect Membrane Hyperpolarization Sucrose Medium Arachidonic Acid Cascade Diuretic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • J. Diez
    • 1
  • I. Colina
    • 1
  • J. Quiroga
    • 1
  • R. Diaz-Tejeiro
    • 1
  • L. Yap
    • 1
  • F. Maduell
    • 1
  • P. Errasti
    • 1
  • A. Purroy
    • 1
  • J. Prieto
    • 1
  1. 1.Division of Nephrology & Department of MedicineUniversity Clinic, University of NavarraPamplonaSpain

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