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Lack of Evidence for Na/K ATPase Inhibition as a Cause of Low Renin Human Hypertension

  • R. Pedrinelli
  • A. Clerico
  • L. Graziadei
  • S. Taddei
  • M. Del Chicca
  • A. Salvetti
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

A circulating Na/K ATPase(sodium pump) inhibiting factor might cause hypertension in man. Furthermore, more recent evidence suggests that suppressed peripheral PRA values might be a marker for the presence of that factor in human hypertension(for a review see 1). We designed this study to further assess that possibility. Our specific aims were to evaluate whether biochemical or functional indices of Na/K ATPase inhibition are present in low renin human hypertension, either in primary aldosteronism (PA)or in the so called low renin essential hypertension(LREH). As controls, normal renin essential hypertensives(NREH) were taken.

Keywords

Primary Aldosteronism Sodium Pump ATPase Inhibition Forearm Vascular Resistance Bilateral Adrenal Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • R. Pedrinelli
    • 1
  • A. Clerico
    • 2
  • L. Graziadei
    • 1
  • S. Taddei
    • 1
  • M. Del Chicca
    • 3
  • A. Salvetti
    • 1
  1. 1.Hypertension Unit, I Clinica MedicaUniversity of PisaPisaItaly
  2. 2.Patologia MedicaUniversity of PisaPisaItaly
  3. 3.Istituto di Fisiologia Clinica, CNRUniversity of PisaPisaItaly

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