Lack of Evidence for Na/K ATPase Inhibition as a Cause of Low Renin Human Hypertension
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A circulating Na/K ATPase(sodium pump) inhibiting factor might cause hypertension in man. Furthermore, more recent evidence suggests that suppressed peripheral PRA values might be a marker for the presence of that factor in human hypertension(for a review see 1). We designed this study to further assess that possibility. Our specific aims were to evaluate whether biochemical or functional indices of Na/K ATPase inhibition are present in low renin human hypertension, either in primary aldosteronism (PA)or in the so called low renin essential hypertension(LREH). As controls, normal renin essential hypertensives(NREH) were taken.
KeywordsPrimary Aldosteronism Sodium Pump ATPase Inhibition Forearm Vascular Resistance Bilateral Adrenal Hyperplasia
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