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Effect of Thiazides and Amiloride on the Phosphorylation Status of the Red Cell Membrane Anion Carrier

  • B. Baggio
  • G. Marzaro
  • G. Gambaro
  • F. Marchini
  • A. Borsatti
  • G. Clari
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Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

We have recently reported an enhanced red blood cell (RBC) oxalate self-exchange in idiopathic calcium-oxalate nephrolithiasis (1,2) which seems to be linked to an anomalous phosphorylation of band 3 protein (the anion carrier) in RBC ghosts (3). We have also shown that the RBC anomaly can be corrected “in vivo” by the administration of hydrochlorothiazide (HCT) and amiloride (A) (2). Aim of the present study was the search of a bound between these drugs and band 3 phosphorylation.

Keywords

Internal Medicine Protein Kinase Membrane Protein Phosphorylation Status Direct Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Baggio, B., Gambaro, G., Marchini, F., Cicerello, E., Borsatti, A. Lancet ii: 12–13, 1984.CrossRefGoogle Scholar
  2. 2.
    Baggio, B., Gambaro, G., Marchini, F., Cicerello, E., Tenconi, R., Clementi, M., Borsatti, A. New Engl. J. Med. 314: 599–604, 1986.PubMedCrossRefGoogle Scholar
  3. 3.
    Baggio, B., Clari, G., Marzaro, G., Gambaro, G., Borsatti, A., Moret, V. IRCS Med. Sc. 14: 368–369, 1986.Google Scholar
  4. 4.
    Holland, R., Woodgett, J.R., Hardie, D.G. FEBS Lett. 154: 269–273, 1983.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • B. Baggio
    • 1
  • G. Marzaro
    • 1
  • G. Gambaro
    • 1
  • F. Marchini
    • 1
  • A. Borsatti
    • 1
  • G. Clari
    • 2
  1. 1.Institute of Internal MedicineUniversity of Padova, Policlinico UniversitarioPadovaItaly
  2. 2.Institute of Biological ChemistryUniversity of VeronaItaly

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