Effect of Thiazides and Amiloride on the Phosphorylation Status of the Red Cell Membrane Anion Carrier
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We have recently reported an enhanced red blood cell (RBC) oxalate self-exchange in idiopathic calcium-oxalate nephrolithiasis (1,2) which seems to be linked to an anomalous phosphorylation of band 3 protein (the anion carrier) in RBC ghosts (3). We have also shown that the RBC anomaly can be corrected “in vivo” by the administration of hydrochlorothiazide (HCT) and amiloride (A) (2). Aim of the present study was the search of a bound between these drugs and band 3 phosphorylation.
KeywordsInternal Medicine Protein Kinase Membrane Protein Phosphorylation Status Direct Binding
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