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In Vitro Effects of d(+) And l(-) Ozolinone on Sodium and Potassium Fluxes in Human Erythrocytes

  • C. Guarena
  • R. Boero
  • C. Rosati
  • G. Forneris
  • G. Beltrame
  • F. Quarello
  • G. Piccoli
Chapter
  • 13 Downloads
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Several observations suggest that diuretic drugs may decrease renal Na reabsorption by direct inhibition of Na transport carrier in different segments of the nephron [1,2]. Ouabain inhibits basolateral sodium reabsorption, which is catalyzed by the Na, K pump; loop diuretics, like furosemide and bumetanide, cause natriuresis by inhibition of the Na, K, Cl cotransport system, which is located in the luminal side of Henle’s loop cells.

Keywords

Human Erythrocyte Tienilic Acid Passive Membrane Hypertensive Drug Diuretic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Doucet, A.In: Actualités Nephrologies Hôp. Meeker, Flammarion Paris, 1984, pp. 7–64.Google Scholar
  2. 2.
    Burg, M.B. Kidney Int. 22: 454–464, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Cusi, D., Garay, R.P. Molec. Pharm. 19: 438–443, 1981.PubMedGoogle Scholar
  4. 4.
    Garay, R.P., Nazaret, C., Diez, J., Etienne, A., Bourgain, R., Braquet, P., Esanu, A. Bioch. Pharm. 33: 2013–2020, 1984.CrossRefGoogle Scholar
  5. 5.
    Greven, J., Defrain, W., Glaser, K., et al. Europ. J. Physiol. 384: 57–68, 1980.CrossRefGoogle Scholar
  6. 6.
    Boero, R., Quarello, F., Guarena, C., Rosati, C., Piccoli, G. Clin. Sci. 69: 709–712, 1985.PubMedGoogle Scholar
  7. 7.
    Greven, J. Heindereick, O. Arzneiinttelforschung 27: 1755–1757, 1977.Google Scholar
  8. 8.
    Braquet, P., Deby, C., Garay, R.P., Larrue, J., Bourgain, R. Lancet i: 1218–1219, 1983.CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • C. Guarena
    • 1
  • R. Boero
    • 1
  • C. Rosati
    • 1
  • G. Forneris
    • 1
  • G. Beltrame
    • 1
  • F. Quarello
    • 1
  • G. Piccoli
    • 1
  1. 1.Divisioni di Nefrologia e Dialisi dell’Ospedale Maggiore di S. Giovanni BattistaTorinoItaly

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