The Effects of Diuretics on Salt Transport in Renal Diluting Segments
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The purpose of this paper is to communicate recent work from our laboratory pertaining to the mechanism of the ADH-induced increase in salt absorption in the medullary thick ascending limb of Henle’s loop (mTALH) of mice. The specialized transport properties of the thick ascending limb of Henle’s loop enable this segment of the nephron to dissociate salt and water absorption. Sodium chloride absorption by the cortical and medullary thick ascending limb is responsible for urinary dilution, since these segments are water-impermeable, as well as urinary concentration by creating a hypertonic medullary interstitium. The primary site of action of the “loop” diuretics, the TALH absorbs roughly 15% of the filtered sodium load.
KeywordsApical Membrane Basolateral Membrane Paracellular Pathway Sodium Chloride Absorption Paired Experiment
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