Voltage-Driven Calcium Reabsorption in Diluting Segment: INHIBITION by Furosemide but Not by Calcium Antagonists

  • P. Dietl
  • H. Oberleithner
Part of the Developments in Nephrology book series (DINE, volume 18)


The mechanisms of the calciuretic effect of furosemide was investigated in the diluting segment with electrophysiological methods. Furosemide completely inhibited Ca-reabsorption and reduced transepithelial voltage to zero. Ca-reabsorption revealed a linear voltage dependence. Nifedipine failed to block a transcellular route of Ca-reabsorption. From these data we conclude that Ca-reabsorption occurs paracellularly and furosemide reduces its electrical driving force.


Electrophysiological Method Transepithelial Potential Difference Luminal Perfusion Transepithelial Voltage NaCI Reabsorption 
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  1. 1.
    Greger, R. Physiol. Rev. 65 (3): 761–797, 1984.Google Scholar
  2. 2.
    Oberleithner, H., Guggino, W., Giebisch, G. Am. J. Physiol. 242: F331–F339, 1982.PubMedGoogle Scholar
  3. 3.
    Bourdeau, J.E., Burg, M.B. Am. J. Physiol. 5: F357–F364, 1979.Google Scholar
  4. 4.
    Imai, M. Pflügers Arch. 374: 255–263, 1978.PubMedCrossRefGoogle Scholar
  5. 5.
    Fleckenstein, A. Ann. Rev. Pharmacol. Toxicol. 17: 149–166, 1977.CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • P. Dietl
    • 1
  • H. Oberleithner
    • 1
  1. 1.Department of PhysiologyUniversity of Würzburg Medical SchoolWürzburgGermany

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