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Influence of Renal Failure on the Pharmacokinetics of Cicletanine

  • P. Jungers
  • C. Divine
  • J. L. Durand
  • P. Y. Chambrin
  • Ph. Chauveau
  • T. Loubaris
  • D. Ganeval
  • G. Fredj
Chapter
  • 12 Downloads
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Cicletanine chlorhydrate (C) is the first of the furopyridines, a new class of antihypertensives. At low therapeutic doses C reduces peripheral vascular resistance and increases arterial compliance. At higher doses, a natriuretic effect is added. C exerts its antihypertensive action through vascular H1 and H3 receptors antagonism and increased prostacyclin release.

Keywords

Normal Renal Function Arterial Compliance Peripheral Vascular Resistance Renal Failure Patient Natriuretic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • P. Jungers
    • 1
  • C. Divine
    • 2
  • J. L. Durand
    • 2
  • P. Y. Chambrin
    • 2
  • Ph. Chauveau
    • 1
  • T. Loubaris
    • 1
  • D. Ganeval
    • 1
  • G. Fredj
    • 2
  1. 1.Department of NephrologyNecker HospitalParisFrance
  2. 2.Department of Clinical PharmacologyLa Sal pétri ère HospitalParisFrance

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