Influence of Renal Failure on the Pharmacokinetics of Cicletanine
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Cicletanine chlorhydrate (C) is the first of the furopyridines, a new class of antihypertensives. At low therapeutic doses C reduces peripheral vascular resistance and increases arterial compliance. At higher doses, a natriuretic effect is added. C exerts its antihypertensive action through vascular H1 and H3 receptors antagonism and increased prostacyclin release.
KeywordsNormal Renal Function Arterial Compliance Peripheral Vascular Resistance Renal Failure Patient Natriuretic Effect
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