Changes in Furosemide Pharmacokinetics Induced by Dehydration

  • Per Sjöström
  • Bo Odlind
  • Björn Beermann
  • Margareta Hammarlund-Udenaes
Part of the Developments in Nephrology book series (DINE, volume 18)


Furosemide (F) is active from the luminal side of the thick ascending loop of Henle (1, 2). Changes in its renal clearance (Cr) should therefore influence the diuretic response. F has a Cr of around 100 ml/min and a somewhat lower nonrenal clearance (3). Binding of F to plasma albumin is very high (98 to 99%; ref.3), and the major part of its Cr is due to active tubular secretion by the organic acid transport system (2). This communication concerns changes in F pharmacokinetics, particularly factors behind reduced renal delivery of F as seen during dehydration.


Tubular Secretion Renal Plasma Flow Plasma Albumin Luminal Side Filtration Fraction 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • Per Sjöström
    • 1
  • Bo Odlind
    • 2
  • Björn Beermann
    • 3
  • Margareta Hammarlund-Udenaes
    • 2
  1. 1.Department of Internal MedicineCentral County HospitalÖrebroSweden
  2. 2.University HospitalUppsalaSweden
  3. 3.HuddingeSweden

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