Changes in Furosemide Pharmacokinetics Induced by Dehydration
- 14 Downloads
Furosemide (F) is active from the luminal side of the thick ascending loop of Henle (1, 2). Changes in its renal clearance (Cr) should therefore influence the diuretic response. F has a Cr of around 100 ml/min and a somewhat lower nonrenal clearance (3). Binding of F to plasma albumin is very high (98 to 99%; ref.3), and the major part of its Cr is due to active tubular secretion by the organic acid transport system (2). This communication concerns changes in F pharmacokinetics, particularly factors behind reduced renal delivery of F as seen during dehydration.
KeywordsTubular Secretion Renal Plasma Flow Plasma Albumin Luminal Side Filtration Fraction
Unable to display preview. Download preview PDF.
- 6.Hall S, Rowland M. J Pharmacol Exp Ther 223:263–268, 1985.Google Scholar