Tubular Effects of Atrial Extract and of Atriopeptin III in Conscious Rats
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The exact mechanisms underlying the diuretic and natriuretic effects of the newly discovered atrial natriuretic peptides (ANP) are still unknown. Hemodynamic effects, such as an increase in total renal plasma flow (RPF) or in medullary and papillary flow may contribute to its diuretic and natriuretic actions. In addition, a rise in glomerular filtration rate (GFR) by atrial extracts (AE) or synthetic ANP may lead to an increased tubular load of fluid and sodium (for ref. see (1)). However, since the diuretic and natriuretic effects may occur in the absence of changes in RPF or in GFR, a tubular action of ANP was postulated. The present study was therefore undertaken to investigate a potential tubular action as well as the sites of action of crude AE and of synthetic rat atriopeptin III (AP III; 24 amino acids) in conscious rats.
KeywordsGlomerular Filtration Rate Atrial Natriuretic Peptide Renal Plasma Flow Control Urine Natriuretic Effect
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