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Tubular Effects of Atrial Extract and of Atriopeptin III in Conscious Rats

  • H. J. Kramer
  • J. Kipnowski
  • B. Stekle
  • A. Bäcker
  • H. Stelkens
  • H. G. Predel
  • R. Düsing
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

The exact mechanisms underlying the diuretic and natriuretic effects of the newly discovered atrial natriuretic peptides (ANP) are still unknown. Hemodynamic effects, such as an increase in total renal plasma flow (RPF) or in medullary and papillary flow may contribute to its diuretic and natriuretic actions. In addition, a rise in glomerular filtration rate (GFR) by atrial extracts (AE) or synthetic ANP may lead to an increased tubular load of fluid and sodium (for ref. see (1)). However, since the diuretic and natriuretic effects may occur in the absence of changes in RPF or in GFR, a tubular action of ANP was postulated. The present study was therefore undertaken to investigate a potential tubular action as well as the sites of action of crude AE and of synthetic rat atriopeptin III (AP III; 24 amino acids) in conscious rats.

Keywords

Glomerular Filtration Rate Atrial Natriuretic Peptide Renal Plasma Flow Control Urine Natriuretic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kramer, H.J., Lichardus, B. Klin. Wochenschrift (in press) 1986.Google Scholar
  2. 2.
    Kramer, H.J., Kipnowski, J., Stekle, B., Backer, A., Predel, H.G., Düsing, R. Klin. Wochenschrift (in press) 1986.Google Scholar
  3. 3.
    Koseki, C, Hayashi, Y., Torikai, S., Furuya, M., Ohnuma, N., Imai, M. Am. J. Physiol. 250: F210–F216, 1986.PubMedGoogle Scholar
  4. 4.
    Healy, D.P., Fanestil, D.D. Am. J. Physiol. 250: F573–F578, 1986.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • H. J. Kramer
    • 1
  • J. Kipnowski
    • 1
  • B. Stekle
    • 1
  • A. Bäcker
    • 1
  • H. Stelkens
    • 1
  • H. G. Predel
    • 1
  • R. Düsing
    • 1
  1. 1.Division of Nephrology, Medizinische PoliklinikUniversity of BonnW-Germany

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