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Salt Loading in Spontaneously Hypertensive Rats Further Elevates Blood Pressure Despite Enhanced Release of Atrial Natriuretic Peptides and Exaggerated Natriuresis

  • M. Sambhi
  • M. Kohno
  • K. Clegg
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  • 12 Downloads
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

It has been suggested but not established that atrial natriuretic peptides (ANP) may have a role in the mechanisms of hypertension and associated exaggerated natriuresis during volume expansion. The present investigation was undertaken to examine the influence of chronic salt loading on the circulating plasma levels of ANP in spontaneously hypertensive rats (SHR) and to study the concomitant changes in blood pressure as well as urinary excretion of sodium. Normotensive Wistar Kyoto (WKY) rats were studied as controls under the same protocol.

Keywords

Atrial Natriuretic Peptide Salt Loading Hypertensive Animal Atrial Natriuretic Peptide Level Plasma Atrial Natriuretic Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • M. Sambhi
    • 1
  • M. Kohno
    • 1
  • K. Clegg
    • 1
  1. 1.Hypertension Division, Department of Medicine, Sepulveda VA Medical CenterUniversity of California at Los AngelesUSA

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