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Plasma Cardionatrin and Volume and the Renin Angiotensin Aldosterone System in Normotensiye and Hypertensive Pregnancy

  • P. Fievet
  • A. Fournier
  • A. De Bold
  • N. El Esper
  • P. Brunel
  • I. Gregoire
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Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Cardionatrin is the 28 aminoacid atrial natriuretic peptide which is released into the circulation from its storage granules when the atria are stretched, (1,2). This peptide has both remarkable natriuretic and vasodilating properties and suppresses the renin angiotensin aldosterone system. It may therefore be Implicated in the pathogenesis of hypertension. So far it has been investigated only In essential hypertension and shown to be increased (3). It has not yet been evaluated in pregnancy induced hypertension (PIH) or preeclampsia. Therefore we measured plasma concentrations of cardionatrin in pregnant women with normal blood pressure as well as in women with PIH and preeclampsia during pregnancy and after delivery, simultaneouly with their plasma volume, blood uric acid, plasma renin activity (PRA) and plasma concentrations of aldosterone(PA).

Keywords

Pregnant Woman Essential Hypertension Plasma Volume Atrial Natriuretic Peptide Plosma Renin activIty 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • P. Fievet
    • 1
  • A. Fournier
    • 1
  • A. De Bold
    • 2
  • N. El Esper
    • 1
  • P. Brunel
    • 1
  • I. Gregoire
    • 1
  1. 1.Service de NéphrologieChu AmiensFrance
  2. 2.Department of PathologyQueen’s UniversityKingstonCanada

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