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Atrial Natriuretic Peptides (ANP) in Rats with Chronic Renal Failure

  • J. S. Petersen
  • O. M. Bech
  • E. Steiness
  • D. Kirstein
  • S. Christensen
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Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

In chronic renal failure (CRF) sodium balance is maintained until very low levels of glomerular filtration rate, implying that the sodium excretion per functioning nephron must be increased by some adaptive mechanism (1). The aim of the present study was to investigate the role of ANP in the altered renal sodium handling in rats with CRF. CRF was induced by 5/6 nephrectomy and the rats were maintained on a normal (NSD) as well as on a high sodium diet (HSD) in order to stimulate the adaptive changes in renal sodium excretion. The atrial content of ANP was determined by measurering the natriuretic activity of atrial extracts (AE) and P-ANP was determined by radioimmunoassay.

Keywords

Chronic Renal Failure Atrial Natriuretic Peptide Sodium Excretion Atrial Tissue Sodium Loading 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schultze, R.G., Slatopolsky E., Tall B., Walker W., Levy M., Bricker N.S. Trans Assoc Am Physicians 79: 322–329, 1966.PubMedGoogle Scholar
  2. 2.
    de Bold A.J., Borenstein H.B., Veress A.T., Sonnenberg H. Life Sciences 28: 89–94, 1981.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • J. S. Petersen
    • 1
  • O. M. Bech
    • 1
  • E. Steiness
    • 1
  • D. Kirstein
    • 2
  • S. Christensen
    • 1
  1. 1.Department of PharmacologyUniversity of CopenhagenCopenhagenDenmark
  2. 2.LEO Pharmaceutical ProductsBallerupDenmark

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