Atrial Natriuretic Peptides (ANP) in Rats with Chronic Renal Failure
- 12 Downloads
In chronic renal failure (CRF) sodium balance is maintained until very low levels of glomerular filtration rate, implying that the sodium excretion per functioning nephron must be increased by some adaptive mechanism (1). The aim of the present study was to investigate the role of ANP in the altered renal sodium handling in rats with CRF. CRF was induced by 5/6 nephrectomy and the rats were maintained on a normal (NSD) as well as on a high sodium diet (HSD) in order to stimulate the adaptive changes in renal sodium excretion. The atrial content of ANP was determined by measurering the natriuretic activity of atrial extracts (AE) and P-ANP was determined by radioimmunoassay.
KeywordsChronic Renal Failure Atrial Natriuretic Peptide Sodium Excretion Atrial Tissue Sodium Loading
Unable to display preview. Download preview PDF.