The Use of Amiloride Analogs to Probe Adaptations of the Proximal Tubuiar Na+/H+ Antiporter in Response to a Reduction in Renal Mass

  • L. G. Fine
  • E. P. Nord
Part of the Developments in Nephrology book series (DINE, volume 18)


One of the earliest manifestations of an acute reduction in renal mass is an elevation of the glomerular filtration rates of the remaining nephrons. Within 24 hrs of removing one kidney fluid reabsorption is increased in the proximal tubule, providing an effective mechanism for reclaiming the bulk of the increased filtered load of solutes and water. Since this enhanced tubular reabsorption can be demonstrated in vitro, it follows that the adaptation is intrinsic to the tubular epithelial cell and is not dependent upon extratubular factors (1).


Brush Border Membrane Proximal Tubular Cell Brush Border Membrane Vesicle Remnant Kidney Renal Brush Border Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Fine, L.G. Kidney International 29: 619–634, 1986.PubMedCrossRefGoogle Scholar
  2. 2.
    Salehmoghaddam, S., Bradley, T., Mikhail, N., Badie-Dezfooly, B., Nord, E.P., Trizna, W., Kheyfets, R. and Fine, L.G. Lab. Invest. 53 (4): 443, 1985.PubMedGoogle Scholar
  3. 3.
    Hruska, K., Klahr, S. and Hammerman, M. Am. J. Physiol. 242: F17-F22, 1982.PubMedGoogle Scholar
  4. 4.
    Nord, E.P., Hafezi, A., Kaunitz, J., Trizna, W. and Fine, L.G. Am. J. Physiol. 249: F90-F98, 1985.PubMedGoogle Scholar
  5. 5.
    Conn, D.E., Hruska, K., Klahr, S. and Hammerman, M. Am. J. Physiol. 243: F293-F299, 1982.Google Scholar
  6. 6.
    Harris, R.C., Seifter J. and Brenner, B.M. J. Clin. Invest. 74: 1979–1987, 1986.CrossRefGoogle Scholar
  7. 7.
    Vigne, P., Jean, T., Barbry, P., Frelin, C., Fine, L.G. and Lazdunski, M. J. Biol. Chem. 260: 14120–14125, 1985.PubMedGoogle Scholar
  8. 8.
    Vigne, P., Frelin, C., Audinot, M., Borsotto, M., Cragoe Jr., E.J. and Lazdunski, M. Embo. J. 3: 2647–2651, 1984.PubMedGoogle Scholar
  9. 9.
    Nord, E.P., Goldfarb, D., Mikhail, N., Moradeshagi, P., Hafezi, A., Vaystub, S., Cragoe Jr., E. and Fine, L.G. Am. J. Physiol. 250:F539-F550, 1986.PubMedGoogle Scholar
  10. 10.
    Mircheff, A.K., Ives, H.E., Yee, V.J. and Warnock, D.G. Am. J. Physiol. 246:F853-F858, 1984.PubMedGoogle Scholar
  11. 11.
    Larsson, L. and Tisher, CC. Clin. Res. 34: 698A, 1986.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • L. G. Fine
    • 1
  • E. P. Nord
    • 1
  1. 1.Division of Nephrology, Department of Medicine, Center for the Health SciencesUCLA School of MedicineLos AngelesUSA

Personalised recommendations