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Correlation between Blood Pressure and K+ Fluxes in Essential Hypertensive Patients Treated For 2 Years with Cicletanine

  • R. Garay
  • P. Hannaert
  • C. Nazaret
  • E. Deschamps De Paillette
  • G. Juin
  • P. Braquet
Chapter
  • 12 Downloads
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Essential hypertension appears to result from a combination of genetic and environmental factors, of which an excess Na+ intake is the most important (1). In the past ten years, the extensive investigation of Na+ transport in erythrocytes from essential hypertensive patients revealed at least four different and stable Na+ transport abnormalities (for details see ref. 2, 3, 4):
  1. (i)

    [Leak (+)] = increased passive entry of Na+ in about 15 to 30% of human hypertensives (Leak (+) hypertensives).

     
  2. (ii)

    [Co (-)] = decreased ability of the furosemide-sensitive Na+, K+ cotransport system to extrude a cell Na+-load in about 30 to 40% of human hypertensives (Co (-) hypertensives).

     
  3. (iii)

    [Counter (+)] = increased maximal rate of Na+: Li+ countertransport in about 20 to 40% of human hypertensives (Counter (+) hypertensives).

     
  4. (iv)

    [Pump (-)] = decreased apparent affinity of the Na+, K+ pump for internal Na+ in about 5–10% of human hypertensives.

     

Keywords

Blood Pressure Essential Hypertension Antihypertensive Treatment Extensive Investigation Antihypertensive Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dahl, LK. In: Hypertension. (Eds. J. Genest, E. Kolw and O. Kuchel), McGraw-Hill, New York, 1977, pp. 548–559.Google Scholar
  2. 2.
    Garay, R.P. and Nazaret, C. Cli. Sci. 69 613–624, 1985.Google Scholar
  3. 3.
    Garay, R.P., Diez, J. and Braquet, P. In: The sodium pump. (Eds. I. Glynn and C. Ellory) The Company of Biologists Limited, Cambridge, UK, 1985, pp. 657–662.Google Scholar
  4. 4.
    Canessa, M., Spalvins, A., Adragna, N. and Falkner, B. Hypertension. 6: 344–351, 1984.PubMedGoogle Scholar
  5. 5.
    Garay, R., Nazaret, C, Diez, J., Etienne, A., Bourgain, R. Braquet, P. and Esanu, A. Bioch. Pharmacol. 33: 2013–2020, 1984CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • R. Garay
    • 1
  • P. Hannaert
    • 1
  • C. Nazaret
    • 1
  • E. Deschamps De Paillette
    • 2
  • G. Juin
    • 1
  • P. Braquet
    • 2
  1. 1.INSERM U7Hôpital NeckerParisFrance
  2. 2.IHBFrance

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