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Effects of Muzolimine on Cation Transport in Human Erythrocytes

  • A. Montanari
  • A. Guerra
  • E. Sani
  • A. Novarini
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Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

The saluretic agent muzolimine (MZ) induces “in vivo” changes in urinary pattern similar to those observed with loop diuretics, as furosemide (FUR), bumetanide (BUM) or ethacrinic acid (ETHA) (1). These drugs inhibit NaK2Cl cotransport (COT) in both the luminal side: of the thick ascending limb of Henle’s loop (TAL) and in erythrocytes (RBC) (2). Thus, RBC may be an useful model to study the cellular effects of MZ (2). In this paper we studied RBC cation transport pathways in the presence of MZ.

Keywords

Cellular Effect Human Erythrocyte Loop Diuretic Cation Transport Choline Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • A. Montanari
    • 1
  • A. Guerra
    • 1
  • E. Sani
    • 1
  • A. Novarini
    • 1
  1. 1.Istituto di Semeiotica MedicaUniversità di ParmaItaly

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