The cell of origin of Hodgkin’s disease

  • C. W. Berard
Part of the Developments in Oncology book series (DION, volume 32)


Since the detailed descriptions by Sternberg [1] and Reed [2], Hodgkin’s disease has been recognized as a form of lymphoreticular malignancy with distinctive clinical and pathologic features [3]. The neoplastic cells of the disorder, i.e., the Sternberg-Reed cells and their mononuclear counterparts referred to as ‘Hogdkin’s cells’, are considered to be malignant on the basis of their characteristic aneuploidy and clonality (by marker chromosomes) [4, 5]. Unique to Hodgkin’s disease is the fact that such cells are distributed amidst a background of diverse cytologic types, all of which are apparently benign and ‘reactive’. Principal among them are lymphocytes, bland histiocytes, eosinophils, plasma cells, fibroblasts, endothelial cells, and stromal’ cells. Hodgkin’s disease is thus a peculiar cancer in which the malignant cells only rarely comprise more than a small fraction of the bulk of the tumefaction. For this same reason, within the overall spectrum of Hodgkin’s disease, there is marked histologic diversity on the basis of which Jackson and Parker first proposed a subclassification of limited usefulness [6–9]. Far superior is the scheme later put forth by Lukes and Butler [10, 11] and subsequently popularized as the Rye subclassification [12].


Reticulum Cell Malignant Histiocytosis Interdigitating Reticulum Cell Anderson Hospital Lymphoreticular Malignancy 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • C. W. Berard
    • 1
  1. 1.St. Jude Children’s Research HospitalMemphisUSA

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