Chromosome abnormalities in Burkitt lymphoma and Burkitt-type acute lymphoblastic leukemia
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Specific association of non-random chromosomal rearrangements with distinct malignancies is now widely recognized. At the Sixth Human Gene Mapping Workshop in 1981, the best known associations of this type were assembled for publication as a committee report . A greatly enlarged compilation of similar data has appeared as a result of the Seventh Human Gene Mapping Workshop held in 1983 . As many as 54 recurrent associations between a break point and a neoplastic disorder were recorded. The number of disorders involved was 30. During the last year, several new associations of this type have been found. It is becoming increasingly clear that many of these are specifically related to the rearrangement, transcriptional activation, or amplification of cellular oncogenes located close to the breakpoints.
KeywordsChronic Lymphocytic Leukemia Cytogenet Cell African Patient Cellular Oncogene Variant Translocation
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