Oncogenes in human neoplasms

  • G. M. Cooper
Part of the Developments in Oncology book series (DION, volume 32)


The biologic activity of tumor DNA, detected by transfection of NIH 3T3 mouse cells, has led to the identification of transforming genes which are activated in a variety of human and animal neoplasms. The DNA of many tumors efficiently induces transformation of NIH 3T3 cells. In contrast, the DNA of normal cells lacks efficient transforming activity, even the normal DNA of the same individual animals or patients whose tumor DNA induces transformation. These findings imply that the development of many neoplasms involves dominant genetic alterations leading to activation of transforming genes, which are then detectable by their biologic activity in this gene transfer assay.


Transferrin Receptor Burkitt Lymphoma Mouse Mammary Tumor Virus Transforming Gene Transferrin Family 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • G. M. Cooper
    • 1
  1. 1.Dana Farber Cancer Institute and Department of PathologyHarvard Medical SchoolBostonUSA

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