Stage specific transforming genes in lymphoid neoplasms
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Identification of activated cellular transforming genes in a variety of neoplasms has been greatly facilitated by the use of the NIH 3T3 transfection assay. A unique property of the NIH 3T3 cells is that they have the ability to undergo transformation following integration of dominantly acting genes, possibly because they have already progressed some way down the path toward overt malignancy. These cells have the ability to be transformed by a variety of transforming genes and therefore may represent a multi potential cell capable of responding to many different growth stimulatory signals.
KeywordsTransforming Gene Single Phage Secrete Protein Product Thymic Leukemia Overt Malignancy
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