Hodgkin’s disease: Further information derived from cell lines
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Histologically, Hodgkin’s disease (HD) is characterized by a striking cellular pleomorphism with a low percentage of Hodgkin (H) and Sternberg-Reed (SR) cells, which represent the tumor cell population, admixed with nonmalignant cells, e.g., polymorphonuclears, macrophages, B-cells and T-cells. Aneuploidy and clonal development of H and SR cells confirm their neoplastic nature. However, chromosome markers that are specific for HD have not been identified in freshly sampled tumors. The reasons for the presence of non-malignant cells surrounding H- and SR-cells are still unknown. This admixture has been regarded as a type of graft-vs-host reaction.
KeywordsConditioned Medium Nonmalignant Cell Fetal Calf Serum Concentration Human Fetal Liver Cell Hodgkin Cell Line
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