Hodgkin’s disease: Further information derived from cell lines

  • H. Burrichter
  • M. Schaadt
  • C. Kortmann
  • W. Heit
  • E. Schell-Frederick
  • H. Stein
  • V. Diehl
Part of the Developments in Oncology book series (DION, volume 32)


Histologically, Hodgkin’s disease (HD) is characterized by a striking cellular pleomorphism with a low percentage of Hodgkin (H) and Sternberg-Reed (SR) cells, which represent the tumor cell population, admixed with nonmalignant cells, e.g., polymorphonuclears, macrophages, B-cells and T-cells. Aneuploidy and clonal development of H and SR cells confirm their neoplastic nature. However, chromosome markers that are specific for HD have not been identified in freshly sampled tumors. The reasons for the presence of non-malignant cells surrounding H- and SR-cells are still unknown. This admixture has been regarded as a type of graft-vs-host reaction.


Conditioned Medium Nonmalignant Cell Fetal Calf Serum Concentration Human Fetal Liver Cell Hodgkin Cell Line 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • H. Burrichter
    • 1
  • M. Schaadt
    • 1
  • C. Kortmann
    • 2
  • W. Heit
    • 3
  • E. Schell-Frederick
    • 1
  • H. Stein
    • 4
  • V. Diehl
    • 1
  1. 1.Medizinische Universitätsklinik IKölnGermany
  2. 2.Medizinische Hochschule HannoverGermany
  3. 3.UniversitätsklinikUlmGermany
  4. 4.Nuffield Department of PathologyOxfordUK

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