Prognostic significance of cytologic subdivision in nodular sclerosing Hodgkin’s disease: An analysis of 1156 patients

  • K. A. MacLennan
  • M. H. Bennett
  • A. Tu
  • B. Vaughan Hudson
  • M. J. Easterling
  • C. Vaughan Hudson
  • A. M. Jelliffe
Part of the Developments in Oncology book series (DION, volume 32)


Nodular sclerosis is the most commonly recognized histopathologic subtype of Hodgkin’s disease in many studies [1–5]. In the clinical trials of the British National Lymphoma Investigation (BNLI) [6], 75% of the cases have been classified as nodular sclerosis. Cellular nodules may have a wide variety of histologic appearances which may range from a predominance of lymphocytes to lymphocyte depletion with numerous Hodgkin’s cells [7]. A clear need has emerged for further histopathologic subdivision within this group in order to provide additional prognostic information. Several reports on this theme have been published, but the numbers of cases examined in these studies have been rather small [8–13]. In two previous publications we described the prognostic significance of a cytologic subdivision of nodular sclerosing Hodgkin’s disease in a group of laparotomized or Stage IV patients [14] and in a group of patients who had not undergone staging laparotomy [15]. We now present the combined results of our histologic analysis of 1156 cases of nodular sclerosing Hodgkin’s disease included in which are patients from the previous two studies. The prognostic significance of this cytologic subdivision is discussed and the relationship to anatomic stage is reviewed.


Actuarial Survival Lymphocyte Depletion Lacunar Cell Cytologic Appearance Peripheral Blood Lymphocyte Count 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • K. A. MacLennan
    • 1
  • M. H. Bennett
    • 1
  • A. Tu
    • 1
  • B. Vaughan Hudson
    • 1
  • M. J. Easterling
    • 1
  • C. Vaughan Hudson
    • 1
  • A. M. Jelliffe
    • 1
  1. 1.British National Lymphoma Investigation, Department of OncologyThe Middlesex Hospital Medical SchoolLondonUK

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